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品种反应性 主要应用 宿主 格式 抗体类型 R, H IHC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABC821 描述 Anti-AMBRA1 Antibody Alternate Names - AMBRA1
- Activating molecule in BECN1-regulated autophagy protein 1
背景信息 Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Beclin-1, a principal regulator of autophagosome formation (3), is in turn regulated by AMBRA1. AMBRA1 associates with Beclin-1 through a region near its center as determined by yeast two-hybrid assay. Null mutations in this gene in mice resulted in embryonic lethality with severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic death. Furthermore, down-regulation of AMBRA1 in cultured cells though RNA interference decreased the level of rapamycin and nutrient starvation-induced autophagy (4). Multiple isoforms of AMBRA1 are known to exist. 产品信息 格式 Affinity Purified 演示 Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. 应用 应用 Anti-AMBRA1 Antibody is an antibody against AMBRA1 for use in western blotting, IHC & immunofluorescence. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: 5 μg/mL from a representative lot detected AMBRA1 in human brain tissue.
Immunofluorescence Analysis: 20 μg/mL from a representative lot detected AMBRA1 in human brain cells.生物信息 免疫原品种 KLH-conjugated synthetic peptide corresponding to the N-terminus of human AMBRA1. 表位 N-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 RatHuman 抗体类型 Polyclonal Antibody 基因符号 - AMBRA1
纯化方法 Antigen Affinity purified UniProt编号 - Q9C0C7
产品使用声明 质量保证 Evaluated by Western Blotting in rat brain tissue lysate.
Western Blotting Analysis: 2 μg/mL of this antibody detected AMBRA1 in rat brain tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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下一件merck millipore产品：merck millipore,默克密理博,MABN291,Anti-IMPDH1 Antibody, clone 4F9.1
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