merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB2237,Anti-Syntrophin Antibody, clone 1351

  • merck millipore,默克密理博,MAB2237,Anti-Syntrophin Antibody, clone 1351

    产品名称：Anti-Syntrophin Antibody, clone 1351
    产品型号：MAB2237
    Anti-Syntrophin Antibody, clone 1351 detects level of Syntrophin & has been published & validated for use in WB, IH.

    merck millipore,默克密理博,MAB2237,Anti-Syntrophin Antibody, clone 1351

  • 产品介绍
  • merck millipore,默克密理博,MAB2237,Anti-Syntrophin Antibody, clone 1351

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Shk, Rb, M, R, HIHC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB2237
    描述 Anti-Syntrophin Antibody, clone 1351
    Alternate Names
    • syntrophin, beta 1 (dystrophin-associated protein A1,<br />59kDa, basic component 1)
    • 59 kDa dystrophin-associated protein A1 basic component 1
    • Tax interaction protein 43
    • basic beta 1 syntrophin
    • dystrophin-associated protein A1, 59kD, basic component 1
    • syntrophin, beta 1 (dystrophin-associated protein A1, 59kD,<br />basic component 1)
    背景信息 The syntrophins are a family of scaffolding proteins with multiple protein interaction domains that link signaling proteins to dystrophin family members. Each of the three most characterized syntrophins (α, β1, β2) contains a PDZ domain that binds a unique set of signaling proteins including kinases, ion and water channels, and neuronal nitric oxide synthase (nNOS). Despite their ability to bind dystrophin in vitro, neither γ-syntrophin isoform co-localizes with dystrophin in skeletal muscle. Furthermore, γ-syntrophins do not co-purify with dystrophin isolated from mouse tissue. Research suggests that the interaction of γ-syntrophin with dystrophin is transient and potentially subject to regulatory mechanisms. γ1-Syntrophin is highly expressed in brain and is specifically localized in hippocampal pyramidal neurons, Purkinje neurons in cerebellum, and cortical neurons. γ2-Syntrophin is expressed in many tissues including skeletal muscle where it is found only in the subsynaptic space beneath the neuromuscular junction. In both neurons and muscle, γ-syntrophin isoforms localize to the endoplasmic reticulum where they may form a scaffold for signaling and trafficking (Adams, 2006).
    产品信息
    格式 Purified
    控制
    • Rabbit Skeletal Muscle tissue lysate.
    演示 Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3
    应用
    应用 Anti-Syntrophin Antibody, clone 1351 detects level of Syntrophin & has been published & validated for use in WB, IH.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Immunohistochemistry:
    10 µg/mL in rabbit skeletal tissue (See References for details).
    生物信息
    免疫原品种 Whole purified syntrophin from Torpedo californica electric organ postsynaptic membrane.
    表位 Unknown
    克隆 1351
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Cat. # MAB2237 recognizes Syntrophin.
    同种型 IgG1κ
    品种反应性 SharkRabbitMouseRatHuman
    Species Reactivity Note Rabbit, Mouse, Rat, Human & Torpedo. See References for published data.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_021021.3
    Entrez基因汇总 Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally-related genes. [provided by RefSeq]
    基因符号
    • TIP-43
    • 59-DAP
    • A1B
    • BSYN2
    • DAPA1B
    • FLJ22442
    • MGC111389
    • SNT2
    • SNT2B1
    • Syntrophin-2
    纯化方法 Protein G purfied
    UniProt编号
    • Q13884
    UniProt汇总 FUNCTION: Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.

    SUBUNIT STRUCTURE: Monomer and homodimer Probable. Interacts with the other members of the syntrophin family SNTA1 and SNTB2; with the sodium channel proteins SCN4A and SCN5A By similarity. Interacts with the viral HTLV-1 TAX protein and with dystrophin protein DMD and related proteins DTNA and UTRN.

    SUBCELLULAR LOCATION: Cell membrane › sarcolemma; Peripheral membrane protein; Cytoplasmic sideBy similarity. Cell junctionBy similarity. Cytoplasm › cytoskeletonBy similarity. Note= In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions By similarity.

    TISSUE SPECIFICITY: Ubiquitous. Ref.1

    DOMAIN:The PH 1 domain mediates the oligomerization in a calcium dependent manner By similarity.

    The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane By similarity.

    The SU domain binds calmodulin in a calcium-dependent manner By similarity.

    PTM: Phosphorylated by CaM-kinase II By similarity.

    SEQUENCE SIMILARITIES: Belongs to the syntrophin family.

    Contains 1 PDZ (DHR) domain.

    Contains 2 PH domains.

    Contains 1 SU (syntrophin unique) domain.
    产品使用声明
    质量保证 Western Blotting:
    1.0 µg/mL of this lot detected Syntrophin in 15 µg of rabbit skeletal muscle lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8ºC from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB2237,Anti-Syntrophin Antibody, clone 1351

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