merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB1959,Anti-Integrin β1 Antibody, clone P5D2

  • merck millipore,默克密理博,MAB1959,Anti-Integrin β1 Antibody, clone P5D2

    产品名称：Anti-Integrin β1 Antibody, clone P5D2
    产品型号：MAB1959
    Anti-Integrin β1 Antibody, clone P5D2 detects level of Integrin β1 & has been published & validated for use in ELISA, FC, IC, IH & IP.

    merck millipore,默克密理博,MAB1959,Anti-Integrin β1 Antibody, clone P5D2

  • 产品介绍
  • merck millipore,默克密理博,MAB1959,Anti-Integrin β1 Antibody, clone P5D2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHC, ELISA, FC, ICCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB1959
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Integrin β1 Antibody, clone P5D2
    Alternate Names
    • MAB1959Z
    • CD29
    背景信息 Integrin beta 1, also known as CD29, is a 130 kDa transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits (including alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6) to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. Interactions between integrins and the extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression.
    产品信息
    格式 Purified
    控制
    • A431 & HeLa Cells
    • Human tonsil, human skin tissue
    演示 Purified immunoglobulin in 0.02M PB, 0.25M NaCl, pH 7.6, 0.1% sodium azide.
    应用
    应用 Anti-Integrin β1 Antibody, clone P5D2 detects level of Integrin β1 & has been published & validated for use in ELISA, FC, IC, IH & IP.
    主要应用
    • Immunohistochemistry
    • ELISA
    • Flow Cytometry
    • Immunocytochemistry
    应用说明 Immunoprecipitation: A representative lot of this antibody clone was used in immunoprecipitation.

    Immunohistochemistry: A representative lot of this antibody clone was used in immunohistochemistry (acetone fixation, no paraffin embedding).

    ELISA: A representative lot of this antibody was used in ELISA.

    Immunocytochemistry: A representative lot of this antibody clone was used in immunocytochemistry (paraformaldehyde fixation at less than 4%).

    Functional Activity Assay: A representative lot of this antibody clone was used in cell attachment assay of SV-HFO cells with a characteristic spread morphology. In the presence of function-blocking mAbs to β1 integrin (P5D2), the cells attached but no longer spread, and displayed a rounded morphology with many cytoplasmic projections (Iba, K. et al., 2000).
    生物信息
    免疫原品种 Human keratinocytes derived from skin.
    克隆 P5D2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Reacts with Human Integrin Beta 1.
    同种型 IgG2bκ
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_133376.1
    • NM_002211.2
    • NM_033666.1
    • NM_033667.1
    • NM_033668.1
    • NM_033669.1
    Entrez基因汇总 Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene.
    基因符号
    • MSK12
    • ITGB1
    • GPIIA
    • OTTHUMP00000063731
    • OTTHUMP00000046253
    • OTTHUMP00000063733
    • VLAB
    • OTTHUMP00000063732
    • MDF2
    • FNRB
    • CD29
    纯化方法 Protein A purfied
    UniProt编号
    • P05556
    UniProt汇总 FUNCTION: SwissProt: P05556 # Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta- 1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha- 1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha- 3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha- 10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

    SIZE: 798 amino acids; 88465 Da

    SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha- 5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. Interacts with FLNA. Binds LGALS3BP and ITGB1BP3, when associated with alpha-7, but not with alpha-5 (By similarity). Interacts with FLNB and RANBP9. Isoform Beta-1D interacts with ACE2. Isoform Beta-1A interacts with the C-terminal region of FLNC. Interacts with HIV-1 Tat.

    SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Isoform beta-1B does not localize to focal adhesions. Highly enriched in stage I melanosomes.

    TISSUE SPECIFICITY: Isoform beta-1A is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. Isoform beta-1B is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbelical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform beta-1C and isoform beta-1C-2 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform beta-C-2, rather than isoform beta-1C, is selectively expressed in primary T-cells. Isoform beta-1C is expressed in nonproliferating and differentiated prostate gland epithelial cells. Isoform beta-1D is expressed specifically in striated muscle (skeletal and cardiac muscle).

    SIMILARITY: SwissProt: P05556 ## Belongs to the integrin beta chain family. & Contains 1 VWFA domain.
    产品使用声明
    质量保证 Flow Cytometry Analysis:
    4 µg of the antibody was used to detect Integrin β1 in 1x10^6 A431 cells.
    4 µg of the antibody was used to detect Integrin β1 in 1x10^6 HeLa cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB1959,Anti-Integrin β1 Antibody, clone P5D2

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