merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB336,Anti-Syntaxin Antibody, clone SP8

  • merck millipore,默克密理博,MAB336,Anti-Syntaxin Antibody, clone SP8

    产品名称：Anti-Syntaxin Antibody, clone SP8
    产品型号：MAB336
    This Anti-Syntaxin Antibody, clone SP8 is validated for use in ELISA, WB, IH for the detection of Syntaxin.

    merck millipore,默克密理博,MAB336,Anti-Syntaxin Antibody, clone SP8

  • 产品介绍
  • merck millipore,默克密理博,MAB336,Anti-Syntaxin Antibody, clone SP8

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, Ht, PoIHC, ELISA, WBMAscitesMonoclonal Antibody
    描述
    产品目录编号 MAB336
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Syntaxin Antibody, clone SP8
    Alternate Names
    • STX1A
    • Syntaxin 1A
    • Neuron-specific Antigen HPC-1
    产品信息
    格式 Ascites
    演示 Liquid with 0.1% Sodium Azide.
    应用
    应用 This Anti-Syntaxin Antibody, clone SP8 is validated for use in ELISA, WB, IH for the detection of Syntaxin.
    主要应用
    • Immunohistochemistry
    • ELISA
    • Western Blotting
    应用说明 Immunohistochemistry at >1:100-1:200.

    Formalin fixed (fixed <4 weeks)

    Western blotting at 1:100-1:10,000.

    ELISA at 1:500

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Crude synaptic immunoprecipitate (Human).
    克隆 SP8
    宿主 Mouse
    特异性 Syntaxin (34-36 kDa). Reacts with syntaxin expressed in bacterial systems.
    同种型 IgG1
    品种反应性 RatHumanHamsterPig
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_004603.2
    Entrez基因汇总 Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor (MIM 600565) which produces explosive exocytosis (Zhang et al., 1995 [PubMed 7622072]).[supplied by OMIM]
    基因符号
    • p35-1
    • STX1A
    • HPC-1
    • STX1
    • Syntaxin-1A
    UniProt编号
    • Q16623
    UniProt汇总 FUNCTION: SwissProt: Q16623 # Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis.
    SIZE: 288 amino acids; 33023 Da
    SUBUNIT: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds to CPLX1. Binds SYTL4 and STXBP6. Found in a ternary complex with STX1A and SNAP25 (By similarity). Found in a complex with VAMP8 and SNAP23. Interacts with VAPA and SYBU.
    SUBCELLULAR LOCATION: Cell membrane; Single-pass type IV membrane protein. & Isoform 2: Secreted (Probable).
    TISSUE SPECIFICITY: Isoform 1 is highly expressed in embryonic spinal chord and ganglia and in adult cerebellum and cerebral cortex. Isoform 2 is expressed in heart, liver, fat, skeletal muscle, kidney and brain.
    DISEASE: SwissProt: Q16623 # Haploinsufficiency of STX1A may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.
    SIMILARITY: SwissProt: Q16623 ## Belongs to the syntaxin family. & Contains 1 t-SNARE coiled-coil homology domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain frozen at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MAB336,Anti-Syntaxin Antibody, clone SP8

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