• merck millipore,默克密理博,616454,TGF-β RI Kinase Inhibitor IV - CAS 909910-43-6 - Calbiochem
  • merck millipore,默克密理博,616454,TGF-β RI Kinase Inhibitor IV - CAS 909910-43-6 - Calbiochem

    产品名称:TGF-β RI Kinase Inhibitor IV - CAS 909910-43-6 - Calbiochem
    产品型号:616454
    The TGF-β RI Kinase Inhibitor IV, also referenced under CAS 909910-43-6, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Deph More>>

    merck millipore,默克密理博,616454,TGF-β RI Kinase Inhibitor IV - CAS 909910-43-6 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,616454,TGF-β RI Kinase Inhibitor IV - CAS 909910-43-6 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₅H₁₉N₅S909910-43-6
    描述
    概述 A cell-permeable trisubstituted pyrazole compound that has been shown to selectively inhibit ALK-4/5/7-mediated (IC50 = 45, 12, and 7.5 nM, respectively, in luciferase transcription activity assays), but not ALK-1/2/3/6-mediated cellular signaling in Mv1Lu R4-2 transfectants expressing the individual Type I TGF-β receptors. Inhibits TGF-β-induced Smad2-phosphorylation in HaCaT cells and epithelial-to-mesenchymal transition in NMuMG cells at a concentration of 1 µM.
    产品目录编号 616454
    品牌系列 Calbiochem®
    同义词 Transforming Growth Factor-β Type I Receptor Kinase Inhibitor IV, 3-(6-Methylpyridin-2-yl)-4-(4-quinolyl)-1-phenylthiocarbamoyl-1H-pyrazole, A-83-01, ALK5 Inhibitor IV
    参考
    参考 Tojo, M., et al. 2005. Cancer Sci. 96, 791.
    产品信息
    CAS号 909910-43-6
    具有ATP竞争性 N
    形式 Pale yellow solid
    Hill配方 C₂₅H₁₉N₅S
    化学配方 C₂₅H₁₉N₅S
    Molar Mass 421.5
    可逆 N
    结构配方图像
    生物信息
    主靶 ALK-4/5/7
    主靶IC50 45, 12, and 7.5 nM, respectively, in inhibit ALK-4/5/7-mediated luciferase transcription activity assays
    纯度 ≥97% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Harmful
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,616454,TGF-β RI Kinase Inhibitor IV - CAS 909910-43-6 - Calbiochem

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