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merck millipore,默克密理博,616454,TGF-β RI Kinase Inhibitor IV - CAS 909910-43-6 - Calbiochem
产品名称:TGF-β RI Kinase Inhibitor IV - CAS 909910-43-6 - Calbiochem
产品型号:616454
The TGF-β RI Kinase Inhibitor IV, also referenced under CAS 909910-43-6, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Deph More>>
merck millipore,默克密理博,616454,TGF-β RI Kinase Inhibitor IV - CAS 909910-43-6 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₅H₁₉N₅S 909910-43-6 描述 概述 A cell-permeable trisubstituted pyrazole compound that has been shown to selectively inhibit ALK-4/5/7-mediated (IC50 = 45, 12, and 7.5 nM, respectively, in luciferase transcription activity assays), but not ALK-1/2/3/6-mediated cellular signaling in Mv1Lu R4-2 transfectants expressing the individual Type I TGF-β receptors. Inhibits TGF-β-induced Smad2-phosphorylation in HaCaT cells and epithelial-to-mesenchymal transition in NMuMG cells at a concentration of 1 µM. 产品目录编号 616454 品牌系列 Calbiochem®
同义词 Transforming Growth Factor-β Type I Receptor Kinase Inhibitor IV, 3-(6-Methylpyridin-2-yl)-4-(4-quinolyl)-1-phenylthiocarbamoyl-1H-pyrazole, A-83-01, ALK5 Inhibitor IV 参考 参考 Tojo, M., et al. 2005. Cancer Sci. 96, 791. 产品信息 CAS号 909910-43-6 具有ATP竞争性 N 形式 Pale yellow solid Hill配方 C₂₅H₁₉N₅S 化学配方 C₂₅H₁₉N₅S Molar Mass 421.5 可逆 N 结构配方图像 生物信息 主靶 ALK-4/5/7 主靶IC50 45, 12, and 7.5 nM, respectively, in inhibit ALK-4/5/7-mediated luciferase transcription activity assays 纯度 ≥97% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Harmful
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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