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merck millipore,默克密理博,AB1967,Anti-Integrin αIIb Antibody, cytoplasmic domain
产品名称：Anti-Integrin αIIb Antibody, cytoplasmic domain
产品型号：AB1967
Anti-Integrin αIIb Antibody, cytoplasmic domain is an antibody against Integrin αIIb for use in ELISA & IP.
merck millipore,默克密理博,AB1967,Anti-Integrin αIIb Antibody, cytoplasmic domain
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H ELISA Rb Serum Polyclonal Antibody 描述 产品目录编号 AB1967 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Integrin αIIb Antibody, cytoplasmic domain Alternate Names - CD41 Antigen
- Glycoprotein IIb
产品信息 格式 Serum 演示 Whole rabbit serum. Liquid containing no preservative. 应用 应用 Anti-Integrin αIIb Antibody, cytoplasmic domain is an antibody against Integrin αIIb for use in ELISA & IP. 主要应用 - ELISA
应用说明 Immunoprecipitation
ELISA: Direct 1:500 with 5% milk in PBS or TBS at pH 7.4
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide corresponding to the cytoplasmic domain of human integrin alphaIIb
conjugated to KLH. (a.a. 1020-1039, KVGFFKRNRPPLEEDDEEGE)表位 cytoplasmic domain 宿主 Rabbit 特异性 Human integrin alpha Iib 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_000419.3
Entrez基因汇总 ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. 基因符号 - GTA
- ITGA2B
- CD41B
- GPIIb
- HPA3
- GP2B
- ITGAB
- CD41
UniProt编号 - P08514
UniProt汇总 FUNCTION: SwissProt: P08514 # Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
SIZE: 1039 amino acids; 113391 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells.
DISEASE: SwissProt: P08514 # Defects in ITGA2B are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. This autosomal recessive disorder is the most common inherited disease of platelets. GT is characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors.
SIMILARITY: SwissProt: P08514 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20ºC in undiluted aliquots for up to twelve months from date of receipt. Avoid
repeated freeze/thaw cycles.包装信息 数量 100 µL
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