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merck millipore,默克密理博,MAB2152X,Anti-Endoglin Antibody, clone P3D1, Alexa Fluor 488 conjugated
产品名称：Anti-Endoglin Antibody, clone P3D1, Alexa Fluor 488 conjugated
产品型号：MAB2152X
Detect Endoglin using this Anti-Endoglin Antibody, clone P3D1, Alexa Fluor 488 conjugated validated for use in FC & IC.
merck millipore,默克密理博,MAB2152X,Anti-Endoglin Antibody, clone P3D1, Alexa Fluor 488 conjugated
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H ICC, FC M AlexaFluor®488 Monoclonal Antibody 描述 产品目录编号 MAB2152X 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Endoglin Antibody, clone P3D1, Alexa Fluor® 488 conjugated 背景信息 Human endoglin (ancillaryTGF-beta receptor). Endoglin is a transmembrane glycoprotein expressed by vascular endothelial cells. It functions as an ancillary receptor influencing binding of the Transforming Growth Factor beta (TGF-beta) family ligands to signalling receptors. homodimeric integral membrane protein comprised of 95Kd subunits (CD105). CD105 is a component of the TGF-B receptor system and can bind TGF-B1 and TGF-B3 with high affinity but does not bind TGF-B2. CD105 is expressed by vascular endothelial cells and syncytiotrophoblasts of placenta and is weakly expressed by stromalfibroblasts. U937 cells and activated macrophages also expresses CD105. Expression of CD105 is increased on activated endothelium in tissues undergoing angiogenesis, ,such as in tumors, or in cases of wound healing or dermal inflammation. The epitope of clone P3D1 as well as the epitopes of several other endoglin clones is mapped in the this reference: Puchuantes, S et al (1997) Tissue Antigens 50(3):265-76. 产品信息 格式 AlexaFluor®488 演示 Purified immunoglobulin conjugated to Alexa Fluor® 488. Liquid in PBS containing 1% BSA, 0.05% Tween®-20 and 0.05% sodium azide. 应用 应用 Detect Endoglin using this Anti-Endoglin Antibody, clone P3D1, Alexa Fluor 488 conjugated validated for use in FC & IC. 主要应用 - Immunocytochemistry
- Flow Cytometry
应用说明 Immunocytochemistry: 2 μg/mL
Flow cytometry: 0.2 μg per 1 x 106 cells in 100 μL volume. Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Human resting umbilical vein endothelial cells 克隆 P3D1 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Reacts with human endoglin. 同种型 IgG2a 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000118.1
Entrez基因汇总 Endoglin is a homodimeric transmembrane glycoprotein highly expressed by endothelial cells. It is a component of the transforming growth factor beta receptor complex as it binds TGFB1 and TGFB3 with high affinity. Mutations in the endoglin gene produce hereditary hemorrhagic telangiectasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. 基因符号 - endoglin
- ENG
- ORW
- CD105
- HHT1
- END
- FLJ41744
- ORW1
UniProt编号 - P17813
UniProt汇总 FUNCTION: SwissProt: P17813 # Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.
SIZE: 658 amino acids; 70578 Da
SUBUNIT: Homodimer that forms an heteromeric complex with the signaling receptors for transforming growth factor-beta: TGF-beta receptors I and/or II. It is able to bind TGF-beta 1, and 3 efficiently and TGF-beta 2 less efficiently.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Endoglin is restricted to endothelial cells in all tissues except bone marrow.
DISEASE: SwissProt: P17813 # Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300, 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
- Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
储存和货运信息 存储条件 Maintain at 2°-8°C for up to 12 months from date of receipt. 包装信息 数量 100 µg
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