merck millipore,默克密理博,04-1073,Anti-phospho-GluR1 (Ser845) Antibody, clone EPR2148, rabbit monoclonal

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merck millipore,默克密理博,04-1073,Anti-phospho-GluR1 (Ser845) Antibody, clone EPR2148, rabbit monoclonal
产品名称：Anti-phospho-GluR1 (Ser845) Antibody, clone EPR2148, rabbit monoclonal
产品型号：04-1073
Anti-phospho-GluR1 (Ser845) Antibody, clone EPR2148, Rabbit is an antibody against phospho-GluR1 (Ser845) for use in WB.

merck millipore,默克密理博,04-1073,Anti-phospho-GluR1 (Ser845) Antibody, clone EPR2148, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-1073,Anti-phospho-GluR1 (Ser845) Antibody, clone EPR2148, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R, H, M	WB	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	04-1073
描述	Anti-phospho-GluR1 (Ser845) Antibody, clone EPR2148, rabbit monoclonal
Alternate Names	glutamate receptor, ionotropic, AMPA 1 AMPA 1 AMPA-selective glutamate receptor 1 Glutamate receptor ionotropic, AMPA 1
背景信息	Glutamate receptors (GluRs) are a diverse group responsible for mediating most of the excitatory synaptic transmission in the CNS of vertebrates. They can be categorized as ionotropic or metabotropic and subcategorized by their agonist preferences (NMDA, AMPA or Kainic acid). There are four types of AMPA selective GluR subunits (GluR1, GluR2, GluR3 and GluR4). Tetrameric or pentameric combinations of different subunits contributes to the functional diversity of AMPA receptors. AMPA receptors mediate fast synaptic current at most excitatory synapses, with stoichiometry characterized by subtype composition. Although subunit composition of AMPA receptors varies, they must contain at least one edited GluR1 or GluR3 subunit to be calcium permeable (Hollmann & Heinemann, 1994). The critical residue controlling calcium permeability is in the pore loop region. In GluR1, GluR3, and GluR4, this position is occupied by a Gln residue. The insertion or removal of GluR1/GluR4 oligomeric channels from postsynaptic membranes appears to be LTP/LTD activity dependent while GluR2/GluR3 oligomers are continuously cycling.

产品信息
格式	Unpurified
控制	Rat brain lysate
演示	Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

应用
应用	Anti-phospho-GluR1 (Ser845) Antibody, clone EPR2148, Rabbit is an antibody against phospho-GluR1 (Ser845) for use in WB.
主要应用	Western Blotting

生物信息
免疫原品种	Phospho-specific peptide corresponding to residues surrounding Ser845 of human GluR1.
表位	Phosphorylated Ser845
克隆	EPR2148
宿主	Rabbit
特异性	The antibody only detects GluR1 phosphorylated on Ser845.
同种型	IgG
品种反应性	RatHumanMouse
Species Reactivity Note	Human, mouse, and rat.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_000818.2
Entrez基因汇总	Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
基因符号	MGC133252 GLUH1 GLUR1 GLURA GluR-1 GluR-A GluR-K1 HBGR1
修改	Phosphorylation
纯化方法	Unpurified
UniProt编号	P42261

产品使用声明
质量保证	Evaluated by Western Blot on untreated and lambda phosphatase treated rat brain cell lysates. Western Blot Analysis: 1:5,000-10,000 dilution of this antibody was used to detect GluR1 in untreated and lambda phosphatase treated rat brain cell lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20ºC from date of receipt.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.