merck millipore,默克密理博,526559,PI3Kδ Inhibitor, SW30

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Merck Millipore 默克密理愽

merck millipore,默克密理博,526559,PI3Kδ Inhibitor, SW30 - Calbiochem

经验配方
C₂₅H₂₁N₇O₂

描述
概述	A cell permeable, ATP-competitive and selective tolyl quinazolinone inhibitor of PI 3-Kδ (IC₅₀ = 7 nM, 1300 nM, 85000 nM, and 740 nM for PI 3-Kδ PI 3-Kγ PI 3-Kα and PI 3-Kβ, respectively) in an enzymatic assay with an EC₅₀ = 16 nM for PI 3-Kδ and 2.7 µM for PI 3-Kγ in a cell based assay. It elicits an inflammatory marker suppression effect in co-cultures of HUVEC and PBMCs under superantigen stimulated conditions. This compound, at concentrations between 370 nM and 10 µM, leads to a dose-dependent decrease in E-selectin expression. Furthermore, it is not cytotoxic to HUVEC cells.
产品目录编号	526559
品牌系列	Calbiochem®
同义词	2-((4-amino-3-(3-hydroxyprop-1-ynyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one, PI 3-K Inhibitor XIV

参考
参考	Williams, O., et al. 2010. Chem Biol. 17, 123.

生物信息
纯度	>95% by HPLC

理化信息
溶解度	DMSO

储存和货运信息
货运代码	Shipped with Blue Ice or with Dry Ice
毒性	Regulatory Review
储存	-20°C
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

merck millipore,默克密理博,526559,PI3Kδ Inhibitor, SW30 - Calbiochem

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