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品种反应性 主要应用 宿主 格式 抗体类型 H WB, IHC M Purified Monoclonal Antibody 描述 产品目录编号 MABN18 描述 Anti-PINK1 Antibody, clone N4/49 Alternate Names - Parkinson disease (autosomal recessive) 6
- PTEN induced putative kinase 1
- protein kinase BRPK
- serine/threonine-protein kinase PINK1
- PTEN-induced putative kinase protein 1
背景信息 Mutations in the PTEN-induced kinase 1 (PINK1) gene located within the PARK6 locus on chromosome 1p35-p36 have recently been identified in patients with recessive early-onset Parkinson disease. Data suggests that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance. 产品信息 格式 Purified 控制 - Human normal brain tissue
演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This Anti-PINK1 Antibody, clone N4/49 is validated for use in IH, WB for the detection of PINK1. 主要应用 - Western Blotting
- Immunohistochemistry
应用说明 Western Blot Analysis: A previous lot of MABN18 recognized PINK1 in HEK cells and a rat brain LSP, as reported by an independent laboratory (UC Davis/NIH NeuroMab Facility). 生物信息 免疫原品种 Recombinant protein corresponding to human PINK1. 克隆 N4/49 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody recognizes PINK1. 同种型 IgG1κ 品种反应性 Human Species Reactivity Note Demonstrated to react with human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_115785
Entrez基因汇总 This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq]. 基因符号 - BRPK
- PINK1
- PARK6
纯化方法 Protein G purfied UniProt编号 - Q9BXM7
UniProt汇总 FUNCTION: Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
COFACTOR: Magnesium.
SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass membrane protein.
TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development.
PTM: Autophosphorylated.
INVOLVEMENT IN DISEASE: Defects in PINK1 are the cause of Parkinson disease type 6 (PARK6) [MIM:605909]. A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep.
SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Contains 1 protein kinase domain.产品使用声明 质量保证 Evaluated by Immunohistochemistry in human normal brain tissue.
Immunohistochemistry Analysis: A 1:500 dilution of this antibody detected PINK1 in human normal brain tissue.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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