merck millipore,默克密理博,580555,Paclitaxel, Taxus sp. - CAS 33069-62-4

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merck millipore,默克密理博,580555,Paclitaxel, Taxus sp. - CAS 33069-62-4 - Calbiochem
产品名称：Paclitaxel, Taxus sp. - CAS 33069-62-4 - Calbiochem
产品型号：580555
Antitumor and antileukemic agent isolated from the bark of the yew tree.

merck millipore,默克密理博,580555,Paclitaxel, Taxus sp. - CAS 33069-62-4 - Calbiochem

产品介绍

merck millipore,默克密理博,580555,Paclitaxel, Taxus sp. - CAS 33069-62-4 - Calbiochem

重要规格表

经验配方	CAS号
C₄₇H₅₁NO₁₄	33069-62-4

描述
概述	Antitumor and antileukemic agent isolated from the bark of the yew tree. Promotes assembly of microtubules and inhibits tubulin disassembly. An effective agent in blocking HeLa and B16 cells at the G₂/M stage. Inhibits DNA synthesis and stimulates the release of tumor necrosis factor-α. Induces apoptosis in murine mammary carcinoma MCA-4 and ovarian carcinoma OCA-1 tumors.
产品目录编号	580555
品牌系列	Calbiochem®
同义词	Baccatin III N-benzyl-β-phenylisoserine Ester, TAXOL^®

参考
参考	Derry, W.B., et al. 1995. Biochemistry 34, 2203. Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297. Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847. Hornback, N.B., et al. 1994. In Vivo 8, 819. Manthey, C.L., et al. 1992. J. Immunol. 149, 2459. Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646. Ding, A.H., et al. 1990. Science 248, 370. Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101. Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.

参考

Derry, W.B., et al. 1995. Biochemistry 34, 2203.
Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
Hornback, N.B., et al. 1994. In Vivo 8, 819.
Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646.
Ding, A.H., et al. 1990. Science 248, 370.
Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.

产品信息
CAS号	33069-62-4
具有ATP竞争性	N
形式	White solid
Hill配方	C₄₇H₅₁NO₁₄
化学配方	C₄₇H₅₁NO₁₄
Molar Mass	853.9
可逆	N
结构配方图像

生物信息
主靶	Promotes assembly of microtubules and inhibits tubulins disassembly
纯度	≥97% by HPLC

理化信息
细胞可渗透	N
溶解度	DMSO or MeOH

GHS安全信息
RTECS	DA8340700

安全信息
R相	R: 37/38-41-46-60 Irritating to respiratory system and skin. Risk of serious damage to eyes. May cause heritable genetic damage. May impair fertility.
S相	S: 22-26-36/37/39-45 Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Carcinogenic / Teratogenic
储存	-20°C
避光	Protect from light
防潮	Protect from moisture
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.