merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB1988,Anti-Integrin α2 Antibody, clone 10G11

  • merck millipore,默克密理博,MAB1988,Anti-Integrin α2 Antibody, clone 10G11

    产品名称：Anti-Integrin α2 Antibody, clone 10G11
    产品型号：MAB1988
    This Anti-Integrin α2 Antibody, clone 10G11 is validated for use in IH, FUNC for the detection of Integrin α2.

    merck millipore,默克密理博,MAB1988,Anti-Integrin α2 Antibody, clone 10G11

  • 产品介绍
  • merck millipore,默克密理博,MAB1988,Anti-Integrin α2 Antibody, clone 10G11

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB1988
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Integrin α2 Antibody, clone 10G11
    Alternate Names
    • CD49b,VLA-2, CLB-tromb/4
    • CD49b,VLA-2
    产品信息
    格式 Purified
    演示 Liquid in 20mM Tris, 150mM NaCl, pH 8.0, containing 1%BSA (w/v) and 0.1% sodium azide as a preservative.
    应用
    应用 This Anti-Integrin α2 Antibody, clone 10G11 is validated for use in IH, FUNC for the detection of Integrin α2.
    主要应用
    • Immunohistochemistry
    应用说明 Immunofluorescence

    Flow Cytometry: Use 20uL undiluted antibody per 100uL of 0.5-1 x 106 cells.



    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Human T lymphocytes
    克隆 10G11
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Directed against the a2 human integrin (CD49b antigen, GPIa or VLA-2 alpha chain), which can form distinct complexes with the CD29-antigen (GPIIa or VLA beta-chain), resulting in the VLA-2 complex which is expressed on human platelets. Reacts with platelets, long-term cultivated T lymphocytes and activated T lymphocytes. In immunohistology it reacts with thymocytes, epithelial cells of a variety of tissues, peripheral nerves, fibroblasts, osteoclasts, glomerular mesangium and most non-hematopoietic adherent cell lines.
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_002203.3
    Entrez基因汇总 This gene product belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including, T cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling.
    基因符号
    • GPIa
    • ITGA2
    • CD49B
    • VLAA2
    • VLA-2
    • CD49b
    • BR
    UniProt编号
    • P17301
    UniProt汇总 FUNCTION: SwissProt: P17301 # Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
    SIZE: 1181 amino acids; 129295 Da
    SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    DOMAIN: SwissProt: P17301 The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
    SIMILARITY: Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats. & Contains 1 VWFA domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at 2-8°C in undiluted aliquots for up to 12 months from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB1988,Anti-Integrin α2 Antibody, clone 10G11

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