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merck millipore,默克密理博,23-048,Parkin Protein, active, 10 µg
产品名称:Parkin Protein, active, 10 µg
产品型号:23-048
Active, full length, human recombinant human Parkin. N-terminal 6His-tagged. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.
merck millipore,默克密理博,23-048,Parkin Protein, active, 10 µg
- 产品介绍
重要规格表
主要应用 品种 级联部件 EA Human E3 描述 产品目录编号 23-048 品牌系列 Upstate
商名 - Upstate
描述 Parkin Protein, active, 10 µg 长描述 N-terminal 6His-tagged, recombinant human Parkin full length, expressed by baculovirus in Sf21 insect cells. Purified using immobilized metal affinity chromatography. Alternate Names - PRKN
- Parkinson juvenile disease protein 2
- PARK2
背景信息 Parkin is an E3-ubiquitin ligase belonging to the RBR (RING – In Between RING – RING) family. Mutations in Parkin that result in a loss-of-function are the most frequent cause of familial Parkinson’s disease and are responsible for a large percentage of autosomal recessive juvenile parkinsonism (AR-JP). In addition to its auto-ubiquitination, Parkin can also ubiquitinate various substrates, including the CDK2-interacting protein cyclin E1, the a-synuclein-interacting protein synphilin-1, the synaptic vesicle-associated CDC-rel1 and the p38 subunit of aminoacyl-tRNA synthetase/JTV-1. Ubiquitination of substrates occurs in conjunction with the E2 enzymes UbcH7, UbcH8 or UbcH13/Uev1. 应用 应用 Active, full length, human recombinant human Parkin. N-terminal 6His-tagged. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays. 主要应用 - Enzyme Assay
生物信息 品种 Human 级联部件 E3 Entrez基因编号 - GenBank NM_004562
纯化方法 Purified using immobilized metal affinity chromatography. 产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
包装信息 数量 10 µg
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