merck millipore,默克密理愽
  • merck millipore,默克密理博,MABT18,Anti-Integrin alpha5 (CD49e) Antibody, clone MFR5 (5H10-27)

  • merck millipore,默克密理博,MABT18,Anti-Integrin alpha5 (CD49e) Antibody, clone MFR5 (5H10-27)

    产品名称：Anti-Integrin alpha5 (CD49e) Antibody, clone MFR5 (5H10-27)
    产品型号：MABT18
    This Anti-Integrin alpha5 (CD49e) Antibody, clone MFR5 (5H10-27) is validated for use in FC for the detection of Integrin alpha5 (CD49e).

    merck millipore,默克密理博,MABT18,Anti-Integrin alpha5 (CD49e) Antibody, clone MFR5 (5H10-27)

  • 产品介绍
  • merck millipore,默克密理博,MABT18,Anti-Integrin alpha5 (CD49e) Antibody, clone MFR5 (5H10-27)

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    MFCRPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABT18
    描述 Anti-Integrin alpha5 (CD49e) Antibody, clone MFR5 (5H10-27)
    Alternate Names
    • CD49e antigen
    • integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
    • CD49 antigen-like family member E
    • fibronectin receptor, alpha subunit
    • Integrin alpha-F
    • very late activation protein 5, alpha subunit
    • Fibronectin receptor subunit alpha
    • integrin alpha-5
    背景信息 CD49e is a member of a large integrin family of adhesion molecules. CD49e has been found to be involved in growth, motility, survival, cytoskeletal motility and control of gene expression. CD49e specifically is thought to be a receptor for fibronectin and, in some cell types, may play a part in growth and survival. Research has shown that with high levels of CD49e, tumor cell growth rates were diminished. It may also defend cells against apoptosis through mitogen deficiency.
    产品信息
    格式 Purified
    控制
    • BALB/c thymus
    演示 Purified rat monoclonal IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Anti-Integrin alpha5 (CD49e) Antibody, clone MFR5 (5H10-27) is validated for use in FC for the detection of Integrin alpha5 (CD49e).
    主要应用
    • Flow Cytometry
    生物信息
    免疫原品种 Mouse mast cell line MC/9
    克隆 MFR5 (5H10-27)
    宿主 Rat
    同种型 IgG2a
    品种反应性 Mouse
    Species Reactivity Note Demonstrated to react with mouse.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_034707
    基因符号
    • FNRA
    • ITGA5
    • VLA-5
    • CD49e
    • VLA5A
    纯化方法 Protein G Purified
    UniProt编号
    • P11688
    UniProt汇总 FUNCTION: Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. May play a role in the survival of adult skeletal muscle.

    SUBUNIT STRUCTURE: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with NISCH. Interacts with HPS5 (By similarity). Interacts with RAB21 and COMP (By similarity).

    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

    DISRUPTION PHENOTYPE: Mice die at day E10-E11. They show both extraembryonic and embryonic vascular defects, and severe abnormalities in the development of the posterior trunk.

    SEQUENCE SIMILARITIES: Belongs to the integrin alpha chain family.

    Contains 7 FG-GAP repeats.
    产品使用声明
    质量保证 Evaluated by Flow Cytometry in BALB/c thymus.

    Flow Cytometry Analysis: 1 µL of this antibody detected CD49e in BALB/c thymus.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MABT18,Anti-Integrin alpha5 (CD49e) Antibody, clone MFR5 (5H10-27)

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