merck millipore,默克密理愽
  • merck millipore,默克密理博,444284,MMP-2/MMP-3 Inhibitor III, PD166793 - CAS 199850-67-4 - Calbiochem

  • merck millipore,默克密理博,444284,MMP-2/MMP-3 Inhibitor III, PD166793 - CAS 199850-67-4 - Calbiochem

    产品名称：MMP-2/MMP-3 Inhibitor III, PD166793 - CAS 199850-67-4 - Calbiochem
    产品型号：444284
    The MMP-2/MMP-3 Inhibitor III, PD166793, also referenced under CAS 199850-67-4, controls the biological activity of MMP-2/MMP-3. This small molecule/inhibitor is primarily used for Protease Inhibitors More>>

    merck millipore,默克密理博,444284,MMP-2/MMP-3 Inhibitor III, PD166793 - CAS 199850-67-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,444284,MMP-2/MMP-3 Inhibitor III, PD166793 - CAS 199850-67-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₇H₁₈BrNO₄S199850-67-4
    描述
    概述 A cell-permeable biphenylsulfonylvaline compound that acts as a potent inhibitor against MMP-2, -3, and -13 (IC50 = 47, 12, and 8 nM, respectively) and a weaker inhibitor against AMP deaminase (20% inhibition at 0.1 µM), MMP-1, -7, -9, and -14 (IC50 = 6.1, 7.2, 7.9, and 0.24 µM, respectively). Shown to offer therapeutic benefits in vivo in various animal models of heart failure and diabetes.
    产品目录编号 444284
    品牌系列 Calbiochem®
    同义词 (S)-2-(4ʹ-Bromo-biphenyl-4-sulfonylamino-3-methylbutyric acid)
    参考
    参考 Paolocci, N., et al. 2006. J. Pharm. Exp. Ther. 317, 506.
    Zhou, Y.P., et al. 2005. Diabetes 54, 2612.
    Peterson, J.T., et al. 2001. Circulation 103, 2303.
    Spinale, F.G., et al. 1999. Circ. Res. 85, 364.
    产品信息
    CAS号 199850-67-4
    具有ATP竞争性 N
    形式 Off-white solid
    Hill配方 C₁₇H₁₈BrNO₄S
    化学配方 C₁₇H₁₈BrNO₄S
    Molar Mass 412.3
    可逆 N
    结构配方图像
    生物信息
    主靶 MMP-2, -3, and -13
    主靶IC50 47, 12, and 8 nM, against MMP-2, -3, and -13, respectively
    纯度 ≥98% by TLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Irritant
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

    merck millipore,默克密理博,444284,MMP-2/MMP-3 Inhibitor III, PD166793 - CAS 199850-67-4 - Calbiochem

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