merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB1952,Anti-Integrin α3 Antibody, clone P1B5

  • merck millipore,默克密理博,MAB1952,Anti-Integrin α3 Antibody, clone P1B5

    产品名称：Anti-Integrin α3 Antibody, clone P1B5
    产品型号：MAB1952
    This Anti-Integrin α3 Antibody, clone P1B5 is validated for use in IC, IH(P), FUNC for the detection of Integrin α3.

    merck millipore,默克密理博,MAB1952,Anti-Integrin α3 Antibody, clone P1B5

  • 产品介绍
  • merck millipore,默克密理博,MAB1952,Anti-Integrin α3 Antibody, clone P1B5

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HICCMAscitesMonoclonal Antibody
    描述
    产品目录编号 MAB1952
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Integrin α3 Antibody, clone P1B5
    Alternate Names
    • CD49c
    背景信息 Integrins are a family of dimeric, transmembrane proteins that mediate cell-cell and extracellular matrix adhesion. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. The integrin family is composed of at least 15 alpha and 8 beta subunits that may form over twenty different alpha-beta non-covalently bound dimeric combinations on the cell surface. The alpha subunits all have some homology to each other, as do the beta subunits. Both of the subunits contribute to the binding of the ligand. Integrin alpha subunits contain seven weak sequence repeats in the N-terminal region, which may be important in ligand binding, and have been predicted to fold cooperatively into a single beta-propeller domain with seven beta-sheets. The alpha-3 subunit (CD49c) is highly concentrated in epithelial cells where it strongly adheres to Laminin-5 and Laminin-5 induced rapid adhesion can be blocked by antibodies against the alpha-3 integrin subunit. The alpha-3 subunit exists in two different splice variants, denoted as "A" and "B". The only difference that results from this differential splicing is a total change in the cytoplasmic domain, while the extracellular domain stays the same. Knock-out mice lacking this subunit show prenatal lethality and abnormalities in the kidneys.
    产品信息
    格式 Ascites
    控制
    • Human foetal foreskin fibroblasts (HFFF), neuroblastomas
    演示 Ascites fluid with 0.1% sodium azide as a preservative.
    应用
    应用 This Anti-Integrin α3 Antibody, clone P1B5 is validated for use in IC, IH(P), FUNC for the detection of Integrin α3.
    主要应用
    • Immunocytochemistry
    应用说明 Suitable for use in attachment inhibition assays using fibroblasts, most epithelial cells, activated lymphocytes on laminin, collagen and fibronectin.

    Immunohistochemistry on human tonsil

    fresh frozen tissue >1:75

    paraffin embedded tissue; protease digestion required: >1:75

    Optimal working dilutions must be determined by end user.
    生物信息
    克隆 P1B5
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Reacts with Human alpha3 integrin.
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_005501.1
    • NM_002204.1
    Entrez基因汇总 ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular-matrix proteins. The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3').
    基因符号
    • CD49C
    • ITGA3
    • GAP-B3
    • CD49c
    • FLJ34704
    • MSK18
    • VLA3a
    • VL3A
    • VCA-2
    • FLJ34631
    • FRP-2
    • GAPB3
    纯化方法 Unpurified
    UniProt编号
    • P26006
    UniProt汇总 FUNCTION: SwissProt: P26006 # Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Alpha- 3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.
    SIZE: 1066 amino acids; 118698 Da
    SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-3 associates with beta-1. Interacts with HPS5.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    TISSUE SPECIFICITY: Isoform alpha-3A is widely expressed. Isoform alpha-3B is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform alpha-3A is strongly expressed on vascular smooth muscle cells, isoform alpha-3B is detected only on endothelial vein cells.
    PTM: Isoform alpha-3A, but not isoform alpha-3B, is phosphorylated on serine residues. Phosphorylation increases after phorbol 12- myristate 13-acetate stimulation.
    SIMILARITY: SwissProt: P26006 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MAB1952,Anti-Integrin α3 Antibody, clone P1B5

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下一件merck millipore产品：merck millipore,默克密理博,343922,5-Fluorouracil - CAS 51-21-8 - Calbiochem


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