merck millipore,默克密理愽
  • merck millipore,默克密理博,AB1924,Anti-Integrin α4 Antibody, cytoplasmic on CT

  • merck millipore,默克密理博,AB1924,Anti-Integrin α4 Antibody, cytoplasmic on CT

    产品名称：Anti-Integrin α4 Antibody, cytoplasmic on CT
    产品型号：AB1924
    Anti-Integrin α4 Antibody, cytoplasmic on C-terminus is an antibody against Integrin α4 for use in ELISA, IP, RIA, WB, IH.

    merck millipore,默克密理博,AB1924,Anti-Integrin α4 Antibody, cytoplasmic on CT

  • 产品介绍
  • merck millipore,默克密理博,AB1924,Anti-Integrin α4 Antibody, cytoplasmic on CT

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, Ch, H, Ht, M, PoIHC, ELISA, WBRbSerumPolyclonal Antibody
    描述
    产品目录编号 AB1924
    Replaces 04-1131
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Integrin α4 Antibody, cytoplasmic on CT
    Alternate Names
    • CD49d
    产品信息
    格式 Serum
    演示 Liquid rabbit antiserum with 0.05% sodium azide.
    应用
    应用 Anti-Integrin α4 Antibody, cytoplasmic on C-terminus is an antibody against Integrin α4 for use in ELISA, IP, RIA, WB, IH.
    主要应用
    • Immunohistochemistry
    • ELISA
    • Western Blotting
    应用说明 ELISA/RIA: 1:1000.

    Western blot: 1:1000, non-reduced conditions; blocking should be with 1-3% BSA. Recognizes a 140 kDa human alpha 4 band under non-reducing conditions.

    Immunohistochemistry: 1:500

    Immunoprecipitation: 5 μL of antibody is sufficient to precipitate alpha4 from 5x106 cells.

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Synthetic peptide derived from the COOH terminal sequence (cytoplasmic domain) of the human alpha 4 integrin subunit.
    表位 cytoplasmic domain, C-terminus
    宿主 Rabbit
    特异性 Integrin alpha 4. Specificity determined by immunoprecipitation from a detergent extract of 35S methionine-labeled lymphoid cells. No cross-reactivity to alpha 1, alpha 2, alpha 3, alpha 5, alpha 6 or alpha V. The antibody recognizes an epitope on the cytoplasmic domain of the protein, and it is thus intracellular.
    品种反应性 RatChickenHumanHamsterMousePig
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_000885.4
    Entrez基因汇总 The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.
    基因符号
    • CD49d
    • ITGA4
    • MGC90518
    • VLA-4
    • IA4
    • CD49D
    UniProt编号
    • P13612
    UniProt汇总 FUNCTION: SwissProt: P13612 # Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
    SIZE: 1038 amino acids; 115333 Da
    SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN, LPXN, and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    DOMAIN: SwissProt: P13612 The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion.
    PTM: Phosphorylation on Ser-1027 inhibits PXN binding.
    SIMILARITY: Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20ºC in undiluted aliquots for up to 12 months upon date of receipt. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB1924,Anti-Integrin α4 Antibody, cytoplasmic on CT

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下一件merck millipore产品：merck millipore,默克密理博,475913,Mycophenolic Acid - CAS 24280-93-1 - Calbiochem


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