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merck millipore,默克密理博,MAB1697,Anti-cAMP-Dependent Protein Kinase II Antibody, Regulatory Subunit α/β, clone RS30
产品名称：Anti-cAMP-Dependent Protein Kinase II Antibody, Regulatory Subunit α/β, clone RS30
产品型号：MAB1697
Detect cAMP-Dependent Protein Kinase II using this Anti-cAMP-Dependent Protein Kinase II Antibody, Regulatory Subunit α/β, clone RS30 validated for use in ELISA, IF & WB.
merck millipore,默克密理博,MAB1697,Anti-cAMP-Dependent Protein Kinase II Antibody, Regulatory Subunit α/β, clone RS30
- 产品介绍
- merck millipore,默克密理博,MAB1697,Anti-cAMP-Dependent Protein Kinase II Antibody, Regulatory Subunit α/β, clone RS30
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Po, B, H WB, ELISA M Purified Monoclonal Antibody 描述 产品目录编号 MAB1697 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-cAMP-Dependent Protein Kinase II Antibody, Regulatory Subunit α/β, clone RS30 产品信息 格式 Purified 演示 Purified immunoglobulin. Liquid in PBS pH 7.4 containing 0.1% sodium azide as a preservative. 应用 应用 Detect cAMP-Dependent Protein Kinase II using this Anti-cAMP-Dependent Protein Kinase II Antibody, Regulatory Subunit α/β, clone RS30 validated for use in ELISA, IF & WB. 主要应用 - Western Blotting
- ELISA
应用说明 Localization of regulatory subunit in normal and tumor cells.
Western blot
Immunofluorescence
ELISA:Bovine1:1,500,000
Porcine1:240,000
Human1:1,000
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Purified regulatory subunit of cAMP-dependant protein kinase type II from bovine brain 表位 Regulatory Subunit alpha/beta 克隆 RS30 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Regulatory subunit of cAMP-dependant protein kinase type II, alpha and beta. 同种型 IgG2a 品种反应性 PigBovineHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_004157.2
Entrez基因汇总 cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). 基因符号 - PRKAR2
- PRKAR2A
- MGC3606
- PKR2
UniProt编号 - P13861
UniProt汇总 FUNCTION: SwissProt: P13861 # Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
SIZE: 404 amino acids; 45518 Da
SUBUNIT: The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Interacts with AKAP4 and CBFA2T3.
TISSUE SPECIFICITY: Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
PTM: Phosphorylated by the activated catalytic chain.
SIMILARITY: SwissProt: P13861 ## Belongs to the cAMP-dependent kinase regulatory chain family. & Contains 2 cyclic nucleotide-binding domains.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at +2-8°C for up to 6 months. 包装信息 数量 100 µg
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