merck millipore,默克密理博,04-437,Anti-Bcl-6 (CT) Antibody, rabbit monoclonal

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merck millipore,默克密理博,04-437,Anti-Bcl-6 (CT) Antibody, rabbit monoclonal
产品名称：Anti-Bcl-6 (CT) Antibody, rabbit monoclonal
产品型号：04-437
Detect Bcl-6 (C-term) using this Anti-Bcl-6 (C-term) Antibody, Rabbit validated for use in IF, IP, WB, IH(P).

merck millipore,默克密理博,04-437,Anti-Bcl-6 (CT) Antibody, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-437,Anti-Bcl-6 (CT) Antibody, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	WB	Rb	Purified	Monoclonal Antibody

描述
产品目录编号	04-437
品牌系列	Upstate
商名	Upstate
描述	Anti-Bcl-6 (CT) Antibody, rabbit monoclonal

产品信息
格式	Purified
演示	In 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.

应用
应用	Detect Bcl-6 (C-term) using this Anti-Bcl-6 (C-term) Antibody, Rabbit validated for use in IF, IP, WB, IH(P).
主要应用	Western Blotting

生物信息
免疫原品种	KLH-conjugated synthetic peptide near the C-terminus of human Bcl-6.
宿主	Rabbit
特异性	Recognizes a region near the C-terminus of human Bcl-6.
同种型	IgG
品种反应性	Human
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_138931.1 NM_001706.2
Entrez基因汇总	The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL.
基因符号	BCL5 BCL6 ZBTB27 BCL-5 ZNF51 BCL-6 LAZ3 BCL6A
UniProt编号	P41182
UniProt汇总	FUNCTION: SwissProt: P41182 # Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis. SIZE: 706 amino acids; 78846 Da SUBUNIT: Interacts with ZBTB7 and BCL6B (By similarity). Interacts with the catalytic domain of HDAC9. SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Expressed in germinal center T and B cells and in primary immature dendritic cells. PTM: Phosphorylated by MAPK1 in response to antigen receptor activation. Phosphorylation induces its degradation by ubiquitin/proteasome pathway. DISEASE: SwissProt: P41182 # Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. & A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. & A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF. SIMILARITY: SwissProt: P41182 ## Contains 1 BTB (POZ) domain. & Contains 6 C2H2-type zinc fingers.

产品使用声明
质量保证	Routinely evaluated by immunoblot.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	2 year at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

储存和货运信息

存储条件

2 year at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.