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品种反应性 主要应用 宿主 格式 抗体类型 M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB15056 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Cryptochrome 2 Antibody Alternate Names - CRY2
产品信息 格式 Affinity Purified 演示 Liquid in PBS containing 0.1% sodium azide. 应用 应用 Anti-Cryptochrome 2 detects levels of Cryptochrome 2 proteins & has been published & validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Synthetic peptide. 宿主 Rabbit 特异性 Cryptochrome 2 [CRY-2]. By Western blot the antibody recognizes a doublet at ~67-70 kDa in mouse brain lysate. 品种反应性 Mouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_021117.2
基因符号 - Cryptochrome-2.
- CRY2
- PHLL2
- HCRY2
- FLJ10332
- KIAA0658
纯化方法 Immunoaffinity purified UniProt编号 - Q49AN0
UniProt汇总 FUNCTION: SwissProt: Q49AN0 # Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK NPAS2-BMAL1 E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK NPAS2-BMAL1 transcriptional activity through stabilizing the unphosphorylated form of BMAL1.
COFACTOR: Binds 1 FAD per subunit (By similarity). & Binds 1 5,10-methenyltetrahydrofolate non-covalently per subunit (By similarity).
SIZE: 593 amino acids; 66947 Da
SUBUNIT: Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with PER1 and PER2 C-terminal domains. Interaction with PER2 inhibits its ubiquitination and vice versa. Interacts with NFIL3 (By similarity).
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated to the nucleus through interaction with other Clock proteins such as PER2 or BMAL1.
TISSUE SPECIFICITY: Expressed in all tissues examined including fetal brain, fibroblasts, heart, brain, placenta, lung, liver, sketal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Highest levels in heart and skeletal muscle.
PTM: Phosphorylation on Ser-266 by MAPK is important for the inhibition of CLOCK-BMAL1-mediated transcriptional activity. Phosphorylation by CSKNE requires interaction with PER1 or PER2.
SIMILARITY: SwissProt: Q49AN0 ## Belongs to the DNA photolyase class-1 family. & Contains 1 DNA photolyase domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8degC in undiluted aliquots for up to 6 months after date of receipt. 包装信息 数量 100 µg
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