merck millipore,默克密理愽
  • merck millipore,默克密理博,196870,BAY 11-7082 - CAS 19542-67-7 - Calbiochem

  • merck millipore,默克密理博,196870,BAY 11-7082 - CAS 19542-67-7 - Calbiochem

    产品名称：BAY 11-7082 - CAS 19542-67-7 - Calbiochem
    产品型号：196870
    The BAY 11-7082, also referenced under CAS 19542-67-7, controls the biological activity of TNF-α. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

    merck millipore,默克密理博,196870,BAY 11-7082 - CAS 19542-67-7 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,196870,BAY 11-7082 - CAS 19542-67-7 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₀H₉NO₂S19542-67-7
    描述
    概述 Potential anti-inflammatory agent that selectively and irreversibly inhibits the TNF-α-inducible phosphorylation of IκBα (IC50 = 10 µM), resulting in a decreased expression of NF-κB and of adhesion molecules. Does not affect constitutive IκBα autophosphorylation. Inhibits TNF-α-induced surface expression of the endothelial-leukocyte cell adhesion molecules E-selectin, VCAM-1, and ICAM-1. A 100 mM (10 mg/483 µl) solution of BAY 11-7082 (Cat. No. 196871) in DMSO is also available is also available.
    产品目录编号 196870
    品牌系列 Calbiochem®
    同义词 (E)3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
    参考
    参考 Kamthong PJ. and Wu, M-C. 2001. Biochem. J. 356.
    Izban, K.F., et al. 2000. Hum. Pathol. 31, 1482.
    Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096.
    产品信息
    CAS号 19542-67-7
    形式 Off-white solid
    Hill配方 C₁₀H₉NO₂S
    化学配方 C₁₀H₉NO₂S
    Molar Mass 207.2
    可逆 N
    结构配方图像
    生物信息
    主靶 TNF-α-inducible phosphorylation of IκBα
    主靶IC50 10 µM inhibiting TNF-α-inducible phosphorylation of IκBα
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,196870,BAY 11-7082 - CAS 19542-67-7 - Calbiochem

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