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品种反应性 主要应用 宿主 格式 抗体类型 M, H WB, FC, IHC R Purified Monoclonal Antibody 描述 产品目录编号 MAB17001-K 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Bim, Clone 14A8 背景信息 Bim (bcl-2-interacting mediator of cell death) is a proapoptotic member of the Bcl-2 family that shares only the BH3 domain with this family. There are three isoforms of Bim: BimEL, BimL, and BimS. Bim is involved in regulating the intrinsic mitochondrial apoptotic pathway by inducing cytochrome c release, which in turn, activates caspase-9 and then caspase-3. Bim also plays a critical role in central and peripheral deletion of T lymphocytes and in controlling B cell homeostasis and activation. BimEL, the long isoform of Bim, is a ~28 kDa protein that is predominantly expressed in T and B cells and is activated by ERK1/2 pathway. The activation of BimEL by ERK1/2 promotes its phosphorylation on serine 65 (serine 69 in human), targeting it for degradation via the proteasome. 产品信息 格式 Purified 应用 主要应用 - Western Blotting
- Flow Cytometry
- Immunohistochemistry
生物信息 宿主 Rat 品种 R IgG2a 品种反应性 MouseHuman 抗体类型 Monoclonal Antibody UniProt编号 - O43521
UniProt汇总 Function: Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosis.
Subunit structure: Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1, and BHRF1. Does not heterodimerize with proapoptotic proteins such as BAD, BOK, BAX or BAK By similarity.
Subcellular location: Endomembrane system; Peripheral membrane protein By similarity. Note: Associated with intracytoplasmic membranes By similarity.
Isoform BimEL: Mitochondrion
Isoform BimL: Mitochondrion
Isoform BimS: Mitochondrion
Isoform Bim-alpha1: Mitochondrion
Tissue specificity: Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are ubiquitously expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney. Ref.3
Domain: The BH3 motif is required for Bcl-2 binding and cytotoxicity.
Sequence similarities: Belongs to the Bcl-2 family.产品使用声明 使用声明 - Minimum order quantity required to qualify. Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Refrigerator (2–8°C) 包装信息 数量 Bulk Vialing size: Please inquire
上一件merck millipore产品：merck millipore,默克密理博,MAB1697,Anti-cAMP-Dependent Protein Kinase II Antibody, Regulatory Subunit α/β, clone RS30
下一件merck millipore产品：merck millipore,默克密理博,ABT120,Anti-Protein Regulator of Cytokinesis 1 (PRC1) Antibody
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