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品种反应性 主要应用 宿主 格式 抗体类型 R, H ICC, WB M Ascites Monoclonal Antibody 描述 产品目录编号 MAB1677 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Cytokeratin 17 Antibody, clone E3 产品信息 格式 Ascites 演示 Liquid 应用 应用 Anti-Cytokeratin 17 Antibody, clone E3 is an antibody against Cytokeratin 17 for use in WB, IC, IH(P). 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Immunohistochemistry on cultured cells (formalin-fixed) and frozen tissue. Also suitable for use on paraffin embedded tissue that has been fixed in ethanol.
Immunoblotting
Final working dilutions must be determined by end user.生物信息 免疫原品种 Keratin purified from rat enterocytes. 克隆 E3 宿主 Mouse 特异性 Human keratin 17, rat keratin with M.W. 40kD. Reveals myoepithelial cells, basal cells and proliferating epithelia in some benign epithelial tumors. 同种型 IgG1 品种反应性 RatHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_000422.1
Entrez基因汇总 KRT17 encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. 基因符号 - 39.1
- KRT17
- CK-17
- PC2
- Cytokeratin-17
- PC
- K17
- Keratin-17
- PCHC1
UniProt编号 - Q04695
UniProt汇总 FUNCTION: SwissProt: Q04695 # May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial stem cells. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair (By similarity).
SIZE: 432 amino acids; 48106 Da
SUBUNIT: Heterodimer of a type I and a type II keratin. KRT17 associates with KRT6 isomers. Interacts with TRADD and SFN (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
TISSUE SPECIFICITY: Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level).
DISEASE: SwissProt: Q04695 # Defects in KRT17 are a cause of pachyonychia congenita type 2 (PC2) [MIM:167210]; also known as Jadassohn-Lewandowsky (J- L) syndrome. PC2 is characterized by onchyogryposis, limited plantar hyperkeratosis, multiple epidermal cysts, abnormal eyebrow and body hair and by the presence of natal teeth. & Defects in KRT17 are a cause of steatocystoma multiplex (SM) [MIM:184500]. SM is a disease characterized by round or oval cystic tumors widely distributed on the back, anterior trunk, arms, scrotum, and thighs. & KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.
SIMILARITY: SwissProt: Q04695 ## Belongs to the intermediate filament family.
MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Short term storage 1 month - +4°C. Long term storage - maintain frozen at -20°C for up to 12 months, aliquoted into convenient samples. Do not thaw and refreeze. 包装信息 数量 100 µL
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