merck millipore,默克密理愽
  • merck millipore,默克密理博,328501,ERO1 Inhibitor II, EN460 - Calbiochem

  • merck millipore,默克密理博,328501,ERO1 Inhibitor II, EN460 - Calbiochem

    产品名称：ERO1 Inhibitor II, EN460 - Calbiochem
    产品型号：328501


    merck millipore,默克密理博,328501,ERO1 Inhibitor II, EN460 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,328501,ERO1 Inhibitor II, EN460 - Calbiochem

    重要规格表

    经验配方
    C₂₂H₁₂ClF₃N₂O₄
    描述
    概述 A cell-permeable thiol reactive enone (EN) compound that selectively interacts with the active-site cysteine of reduced, active form of ERO1α and inhibits its activity (IC50 = 1.9 µM). Also prevents ERO1 re-oxidation both in vitro and in mouse embryonic fibroblasts. Activates the unfolded protein response and protects ER-stressed 293T cells. Can inhibit ERO1α even in the presence of an excess amount of competing thiols. Can inhibit ERO1α even in the presence of an excess amount of competing thiols. EN460 binding to ERO1α is shown to promote the loss of flavin adenine dinucleotide (FAD) from the holoenzyme. Its inhibitory action appears to be irreversible, however addition of FAD and tris(hydroxypropyl)phosphine (Cat. No. 598250) can restore some enzyme activity.
    产品目录编号 328501
    品牌系列 Calbiochem®
    同义词 (Z)-2-Chloro-5-(4,5-dihydro-5-oxo-4-((5-phenyl-2-furanyl)methylene)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzoic acid, (Z)-2-Chloro-5-(5-oxo-4-((5-phenylfuran-2-yl)methylene)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
    参考
    参考 Chu, Y., et al. 2011. Bioorg. Med. Chem. Lett. 21, 1118.
    Blais, J.D., et al. 2010. J. Biol. Chem. 285, 20993.
    产品信息
    形式 Red solid
    Hill配方 C₂₂H₁₂ClF₃N₂O₄
    化学配方 C₂₂H₁₂ClF₃N₂O₄
    Molar Mass 460.8
    结构配方图像
    生物信息
    纯度 ≥99% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,328501,ERO1 Inhibitor II, EN460 - Calbiochem

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