merck millipore,默克密理愽
  • merck millipore,默克密理博,CBL481,Anti-Integrin β1 Antibody, clone TDM29

  • merck millipore,默克密理博,CBL481,Anti-Integrin β1 Antibody, clone TDM29

    产品名称：Anti-Integrin β1 Antibody, clone TDM29
    产品型号：CBL481
    Anti-Integrin β1 Antibody, clone TDM29 is an antibody against Integrin β1 for use in FC, IF & IP.

    merck millipore,默克密理博,CBL481,Anti-Integrin β1 Antibody, clone TDM29

  • 产品介绍
  • merck millipore,默克密理博,CBL481,Anti-Integrin β1 Antibody, clone TDM29

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 CBL481
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Integrin β1 Antibody, clone TDM29
    Alternate Names
    • fibronectin receptor beta chain
    • CD29
    • platelet GPIIa
    • VLA beta1-chain
    产品信息
    格式 Purified
    演示 Immunoglobulin purified by Protein A affinity chromatography and presented in PBS containing 1mg/mL BSA and 10mM sodium azide
    应用
    应用 Anti-Integrin β1 Antibody, clone TDM29 is an antibody against Integrin β1 for use in FC, IF & IP.
    主要应用
    • Flow Cytometry
    生物信息
    免疫原品种 U937 cells
    克隆 TDM29
    宿主 Mouse
    特异性 The antibody reacts with the integrin beta1 chain which is a membrane glycoprotein (130 kDa) that can complex with the 6 different alpha-chains of the VLA's. It is also known as VLA beta1-chain and the fibronectin receptor. The antigen is not expressed on erythrocytes and only weakly stains granulocytes.

    Antigen distribution:
    T cells: 40 ± 10%
    CD4+ cells: 40 ± 20%
    CD8+ cells: 40 ± 15%
    B cells: 20 ± 5%
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_133376.1
    • NM_002211.2
    • NM_033666.1
    • NM_033667.1
    • NM_033668.1
    • NM_033669.1
    Entrez基因汇总 Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene.
    基因符号
    • MSK12
    • ITGB1
    • GPIIA
    • OTTHUMP00000063731
    • OTTHUMP00000046253
    • OTTHUMP00000063733
    • VLAB
    • OTTHUMP00000063732
    • MDF2
    • FNRB
    • CD29
    UniProt编号
    • P05556
    UniProt汇总 FUNCTION: SwissProt: P05556 # Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta- 1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha- 1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha- 3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha- 10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

    SIZE: 798 amino acids; 88465 Da

    SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha- 5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. Interacts with FLNA. Binds LGALS3BP and ITGB1BP3, when associated with alpha-7, but not with alpha-5 (By similarity). Interacts with FLNB and RANBP9. Isoform Beta-1D interacts with ACE2. Isoform Beta-1A interacts with the C-terminal region of FLNC. Interacts with HIV-1 Tat.

    SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Isoform beta-1B does not localize to focal adhesions. Highly enriched in stage I melanosomes.

    TISSUE SPECIFICITY: Isoform beta-1A is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. Isoform beta-1B is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbelical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform beta-1C and isoform beta-1C-2 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform beta-C-2, rather than isoform beta-1C, is selectively expressed in primary T-cells. Isoform beta-1C is expressed in nonproliferating and differentiated prostate gland epithelial cells. Isoform beta-1D is expressed specifically in striated muscle (skeletal and cardiac muscle).

    SIMILARITY: SwissProt: P05556 ## Belongs to the integrin beta chain family. & Contains 1 VWFA domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at 2°-8°C for up to 12 months from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,CBL481,Anti-Integrin β1 Antibody, clone TDM29

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