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merck millipore,默克密理博,MAB1676,Anti-Talin 1 Antibody, NT, a.a. 139-433, clone TA205
产品名称：Anti-Talin 1 Antibody, NT, a.a. 139-433, clone TA205
产品型号：MAB1676
Anti-Talin 1 Antibody, N-terminus, a.a. 139-433, clone TA205 detects level of Talin & has been published & validated for use in IP, WB, IH.
merck millipore,默克密理博,MAB1676,Anti-Talin 1 Antibody, NT, a.a. 139-433, clone TA205
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Rb, H IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MAB1676 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Talin 1 Antibody, NT, a.a. 139-433, clone TA205 产品信息 格式 Purified 演示 Liquid in 0.02 M PB pH 7.6, 0.25 M NaCl containing 0.1% sodium azide. 应用 应用 Anti-Talin 1 Antibody, N-terminus, a.a. 139-433, clone TA205 detects level of Talin & has been published & validated for use in IP, WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunoblotting, recognizes a band at ~230kDa.
Immunoprecipitation
Immunofluorescence
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Human platelet protein 表位 N-terminus, a.a. 139-433 克隆 TA205 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Human Talin. This antibody reacts with an N-terminal epitope in talin, between amino acids 139-433. On microinjection into whole cells MAB1676 disrupts actin stress fibers and focal contacts and inhibits cell motility. 同种型 IgG1 品种反应性 RabbitHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_006289.2
Entrez基因汇总 This gene encodes a cytoskeletal protein which is concentrated in areas of cell-substratum and cell-cell contacts. This protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. 基因符号 - Talin-1.
- TLN1
- talin
- ILWEQ
- KIAA1027
- TLN
非反应性品种 - Mouse
- Rat
UniProt编号 - Q9Y490
UniProt汇总 FUNCTION: SwissProt: Q9Y490 # Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity).
SIZE: 2541 amino acids; 269767 Da
SUBUNIT: Binds with high affinity to vinculin and with low affinity to integrins. Interacts with PIP5K1C and NRAP. Interacts with LAYN.
SUBCELLULAR LOCATION: Cell projection, ruffle membrane (By similarity). Note=Colocalizes with LAYN at the membrane ruffles (By similarity).
SIMILARITY: SwissProt: Q9Y490 ## Contains 1 FERM domain. & Contains 1 I/LWEQ domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain between 2 and 8°C for up to six months. 包装信息 数量 100 µg
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