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merck millipore,默克密理博,05-1535,Anti-Gemin5 Antibody, clone 10G11
产品名称：Anti-Gemin5 Antibody, clone 10G11
产品型号：05-1535
Anti-Gemin5 Antibody, clone 10G11 is a Mouse Monoclonal Antibody for detection of Gemin5 also known as gem (nuclear organelle) associated protein 5 & has been validated in WB, ICC.
merck millipore,默克密理博,05-1535,Anti-Gemin5 Antibody, clone 10G11
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H ICC, WB M Purified Monoclonal Antibody 描述 产品目录编号 05-1535 描述 Anti-Gemin5 Antibody, clone 10G11 Alternate Names - gem (nuclear organelle) associated protein 5
背景信息 Gemin5 is the snRNA-binding component of the SMN complex. The survival of motor neurons (SMN) complex is essential for the biogenesis of small nuclear ribonucleoprotein (snRNP) complexes in eukaryotic cells. Reduced levels of SMN cause the motor neuron degenerative disease, spinal muscular atrophy. As part of this complex, Gemin5 is found in the cytoplasm, nucleoli, and in nuclear bodies called Gemini bodies (gems). Gemin5-containing subunits bind small nuclear RNA independently of the SMN complex and without a requirement for exogenous ATP. ATP hydrolysis is, however, required for displacement of small nuclear RNAs from the Gemin5-containing subunits and their assembly into snRNPs. 产品信息 格式 Purified 控制 - K562 cell lysate
演示 Purified Mouse Monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Gemin5 Antibody, clone 10G11 is a Mouse Monoclonal Antibody for detection of Gemin5 also known as gem (nuclear organelle) associated protein 5 & has been validated in WB, ICC. 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Immunocytochemistry:
A representative lot of this antibody was used by an independent laboratory for immunocytochemistry analysis. See Feng, W., et al. (2005). Hum. Mol. Genet. 14: 1605 - 1611.生物信息 免疫原品种 Histidine-tagged recombinant protein corresponding to human Gemin5. 表位 Unknown 克隆 10G11 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody recognizes Gemin5. 同种型 IgG2aκ 品种反应性 Human Species Reactivity Note Demonstrated to react with human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_056280
Entrez基因汇总 GEMIN5 is part of a large macromolecular complex localized to both the cytoplasm and the nucleus that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), and GEMIN4 (MIM 606969).[supplied by OMIM]. 基因符号 - DKFZp586M1824
- gemin 5
- gemin5
- GEMIN5
- MGC142174
纯化方法 Protein G purfied UniProt编号 - Q8TEQ6
UniProt汇总 FUNCTION: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. GEMIN5 acts as the snRNA-binding protein of the SMN complex.
SUBUNIT STRUCTURE: Part of the core SMN complex that contains SMN1, SIP1/GEMIN2, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Interacts directly with SMN1, SNRPB, SNRPD1, SNRPD2, SNRPD3 and SNRPE.
SUBCELLULAR LOCATION: Nucleus › nucleoplasm. Nucleus › gem. Cytoplasm. Note: Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.
SEQUENCE SIMILARITIES: Belongs to the WD repeat gemin-5 family.
Contains 13 WD repeats.产品使用声明 质量保证 Evaluated by Western Blot in K562 cell lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody detected Gemin5 on 10 µg of K562 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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