merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB1501X,Anti-Actin Antibody, clone C4, Alexa Fluor 488 conjugated

  • merck millipore,默克密理博,MAB1501X,Anti-Actin Antibody, clone C4, Alexa Fluor 488 conjugated

    产品名称：Anti-Actin Antibody, clone C4, Alexa Fluor 488 conjugated
    产品型号：MAB1501X
    Anti-Actin Antibody, clone C4, Alexa Fluor 488 conjugated detects level of Actin & has been published & validated for use in IF.

    merck millipore,默克密理博,MAB1501X,Anti-Actin Antibody, clone C4, Alexa Fluor 488 conjugated

  • 产品介绍
  • merck millipore,默克密理博,MAB1501X,Anti-Actin Antibody, clone C4, Alexa Fluor 488 conjugated

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Ch, HIFMAlexaFluor®488Monoclonal Antibody
    描述
    产品目录编号 MAB1501X
    Replaces MAB1501X
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Actin Antibody, clone C4, Alexa Fluor® 488 conjugated
    Alternate Names
    • MAB1501R
    • MAB1501
    背景信息 Actin is an abundant cytoskeletal protein found in all cells (True, 1990). The protein's 42 kD peptide chain assumes two physical forms: globular actin, which may serve as a cytoplasmic storage pool, and fibrous actin, which, in conjunction with myosin, generates muscle contraction (True, 1990). In non-muscle cells, actin appears to be involved in a variety of functions, such as cell motility, exocytosis, and phagocytosis (True, 1990). Distribution of the six known isoforms of actin - four muscle actins (alpha-skeletal, alpha-vascular smooth, alpha-cardiac, and gamma-enteric smooth) and two cytoplasmic actins (alpha and gamma) is tissue specific (Otey, 1986; Lessard, 1988).
    产品信息
    格式 AlexaFluor®488
    控制
    • HeLa cells
    演示 Purified in PBS with 15 mg/mL BSA and 0.05% NaN3, conjugated to Alexa Fluor 488.
    应用
    应用 Anti-Actin Antibody, clone C4, Alexa Fluor 488 conjugated detects level of Actin & has been published & validated for use in IF.
    主要应用
    • Immunofluorescence
    应用说明 Immunofluorescence: 1:200-1:1000

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Purified chicken gizzard actin (Lessard, 1988).
    表位 a.a. 50-70
    克隆 C4
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 MAB1501X is a pan-actin antibody that binds to an epitope in a highly conserved region of actin; therefore, this antibody reacts with all six isoforms of vertabrate actin (Lessard, 1988). The epitope recognized by the antibody appears to be located in the N-terminal two thirds of the actin molecule, possibly near amino acids 50-70. Reacts with both globular (G) and fillimentous (F) forms of actin and does not interfere with actin polymerization to form filaments, at a ratio as high as one antibody per two actin monomers. However, this antibody does increase the extent of polymerization when used at a lower ratio of antibody to actin. In addition to labeling myotubes, anti-actin stains myoblasts and fibroblasts (Lessard, 1983). Although clone C4 is prepared as an antibody to chicken gizzard muscles actin, it reacts with actins from all vertebrates, as well as with Dictyostelium discoideum and Physarum polycephalum actins (Lessard, 1988).
    同种型 IgG2bκ
    品种反应性 ChickenHuman
    Species Reactivity Note Reacts with human. Expected to react with chicken based on 100% homology. Other species have not been tested.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_001100.3
    Entrez基因汇总 Actin alpha 1 which is expressed in skeletal muscle is one of six different actin isoforms which have been identified. Actins are highly conserved proteins that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.
    基因符号
    • NEM3
    • ACTA1
    • MPFD
    • ASMA
    • NEM1
    • CFTDM
    • ACTA
    • CFTD
    • NEM2
    • Alpha-actin-1
    • CFTD1
    纯化方法 Protein G purfied
    UniProt编号
    • P68032
    • P68133
    • P62736
    • P60709
    • P63261
    • P63267
    UniProt汇总 FUNCTION: SwissProt: P68133 # Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
    SIZE: 377 amino acids; 42051 Da
    SUBUNIT: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Interacts with TTID.
    SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
    DISEASE: SwissProt: P68133 # Defects in ACTA1 are the cause of nemaline myopathy type 3 (NEM3) [MIM:161800]. Nemaline myopathy (NEM) is a form of congenital myopathy characterized by abnormal thread- or rod-like structures in muscle fibers on histologic examination. The clinical phenotype is highly variable, with differing age at onset and severity. & Defects in ACTA1 are a cause of congenital myopathy with excess of thin myofilaments (CM) [MIM:102610]. & Defects in ACTA1 are a cause of congenital myopathy with fiber-type disproportion (CFTD) [MIM:255310]; also known as congenital fiber-type disproportion myopathy (CFTDM). CFTD is a genetically heterogeneous disorder in which there is relative hypotrophy of type 1 muscle fibers compared to type 2 fibers on skeletal muscle biopsy. However, these findings are not specific and can be found in many different myopathic and neuropathic conditions.
    SIMILARITY: SwissProt: P68133 ## Belongs to the actin family.
    MISCELLANEOUS: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
    产品使用声明
    质量保证 Evaluatied on a representative lot by immunofluorescence using HeLa cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    • Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
    储存和货运信息
    存储条件 Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB1501X,Anti-Actin Antibody, clone C4, Alexa Fluor 488 conjugated

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