merck millipore,默克密理博,05-694,Anti-phospho-IGF-IR (Tyr1131)/InsR (Tyr1158) Antibody, clone JY202

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merck millipore,默克密理博,05-694,Anti-phospho-IGF-IR (Tyr1131)/InsR (Tyr1158) Antibody, clone JY202
产品名称：Anti-phospho-IGF-IR (Tyr1131)/InsR (Tyr1158) Antibody, clone JY202
产品型号：05-694
Anti-phospho-IGF-IR (Tyr1131)/InsR (Tyr1158) Antibody, clone JY202 detects level of phospho-IGF-IR (Tyr1131)/InsR (Tyr1158) & has been published & validated for use in IP & WB.

merck millipore,默克密理博,05-694,Anti-phospho-IGF-IR (Tyr1131)/InsR (Tyr1158) Antibody, clone JY202

产品介绍

merck millipore,默克密理博,05-694,Anti-phospho-IGF-IR (Tyr1131)/InsR (Tyr1158) Antibody, clone JY202

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
M, H	WB	M	Protein G Purified	Monoclonal Antibody

描述
产品目录编号	05-694
品牌系列	Upstate
商名	Upstate
描述	Anti-phospho-IGF-IR (Tyr1131)/InsR (Tyr1158) Antibody, clone JY202

产品信息
格式	Protein G Purified
控制	Liver and Pancreatic tissue
演示	Protein G Purified immunoglobulin in 0.1M Tris-glycine, pH 7.4, 0.15M NaCl with 0.05% sodium azide as a preservative, before the addition of 30% glycerol.

应用
应用	Anti-phospho-IGF-IR (Tyr1131)/InsR (Tyr1158) Antibody, clone JY202 detects level of phospho-IGF-IR (Tyr1131)/InsR (Tyr1158) & has been published & validated for use in IP & WB.
主要应用	Western Blotting

生物信息
免疫原品种	peptide containing the amino acids (DI[pY]ET) in which pY corresponds to tyrosine 1131 of human IGF-1 receptor and tyrosine 1158 (mature protein; 1185 of the precursor protein) of human Insulin Receptor
克隆	JY202
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
特异性	Recognizes phosphorylated insulin and PDGF receptors which contain the I Y E motif; slight cross-reactivity detected with EGFR in A431 cells expressing very high levels of EGFR.
同种型	IgG2aκ
品种反应性	MouseHuman
抗体类型	Monoclonal Antibody
Entrez基因编号	A25690
Entrez基因汇总	This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
基因符号	CD221 IGF1R IGFIR MGC18216 MGC142170 JTK13 MGC142172
修改	Phosphorylation
纯化方法	Protein G purfied
UniProt编号	P08069
UniProt汇总	FUNCTION: SwissProt: P08069 # This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. SIZE: 1367 amino acids; 154793 Da SUBUNIT: Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand- binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Expressed in a variety of tissues. PTM: The cytoplasmic domain of the beta subunit is autophosphorylated on tyrosine residues in response to insulin- like growth factor I (IGF I). & Phosphorylation of Tyr-980 is required for IRS1- and SHC1- binding. DISEASE: SwissProt: P08069 # Defects in IGF1R may be a cause in some cases of resistance to insulin-like growth factor 1 (IGF1 resistance) [MIM:270450]. IGF1 resistance is a gowth deficiency disorder characterized by intrauterine growth retardation and poor postnatal growth accompanied with increased plasma IGF1. SIMILARITY: SwissProt: P08069 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. & Contains 3 fibronectin type-III domains. & Contains 1 protein kinase domain.

产品使用声明
质量保证	routinely evaluated by immunoblot on RIPA lysates from stable, transfected 3T3 cells expressing the human IGF-1 receptor treated with IGF-1 and in IGFR-containing immune complexes from IGF-1 treated, but not untreated cell lysates
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.