merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB1222,Anti-Tryptase Antibody, Mast Cell, clone G3

  • merck millipore,默克密理博,MAB1222,Anti-Tryptase Antibody, Mast Cell, clone G3

    产品名称：Anti-Tryptase Antibody, Mast Cell, clone G3
    产品型号：MAB1222
    This Anti-Tryptase Antibody, Mast Cell, clone G3 is validated for use in FC, IH, WB for the detection of Tryptase.

    merck millipore,默克密理博,MAB1222,Anti-Tryptase Antibody, Mast Cell, clone G3

  • 产品介绍
  • merck millipore,默克密理博,MAB1222,Anti-Tryptase Antibody, Mast Cell, clone G3

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWB, FC, IHCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB1222
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Tryptase Antibody, Mast Cell, clone G3
    背景信息 Tryptase is the most abundant secretory granule-derived serine proteinase contained in mast cells. Tryptase has recently been used as a marker for mast cell activation and is involved with allergic response. Tryptase may act as a mitogen for fibroblast lines. Elevated levels of serum tryptase occur in both anaphylactic and anaphylactoid reactions, but a negative test does not exclude anaphylaxis.
    产品信息
    格式 Purified
    控制
    • Human fetal skin lysate
    • Mast cells, basophils
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
    (see product datasheet for specific buffer formulation)
    应用
    应用 This Anti-Tryptase Antibody, Mast Cell, clone G3 is validated for use in FC, IH, WB for the detection of Tryptase.
    主要应用
    • Western Blotting
    • Flow Cytometry
    • Immunohistochemistry
    应用说明 Flow Cytometry Analysis: A previous lot of this antibody has been used on fixed cells in FACS using a conjugated secondary antibody. (Sperr, W., et al., 2001).

    Optimal working dilutions must be determined by end user.
    生物信息
    克隆 G3
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Recognizes Mast cell tryptase. Will show reactivity to basophils but to a lesser degree.
    同种型 IgG1κ
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_003294.3
    Entrez基因汇总 Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.
    基因符号
    • EC 3.4.21.59
    • TPSAB1
    • tryptase-I
    • TPS2
    • Tryptase-1
    • TPSB1
    • TPS1
    • tryptase-III
    纯化方法 Protein G purfied
    UniProt编号
    • Q15661
    UniProt汇总 FUNCTION: SwissProt: P15157 # Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.| Q15661 # Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.
    SIZE: 275 amino acids; 30773 Da
    SUBUNIT: Homotetramer.
    SUBCELLULAR LOCATION: Secreted. Note=Released from the secretory granules upon mast cell activation.
    DOMAIN:SwissProt: P15157
    SIMILARITY: SwissProt: P15157 ## Belongs to the peptidase S1 family. Tryptase subfamily. & Contains 1 peptidase S1 domain. | Q15661 ## Belongs to the peptidase S1 family. Tryptase subfamily. & Contains 1 peptidase S1 domain.
    产品使用声明
    质量保证 Evaluated by western blot on human fetal skin lysate.

    Western Blot Analysis: 0.5 µg/mL of this antibody detected tryptase in 10 µg of human fetal skin lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at 2–8°C for the duration listed on the product datasheet. (See product datasheet for storage conditions)
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB1222,Anti-Tryptase Antibody, Mast Cell, clone G3

上一件merck millipore产品：merck millipore,默克密理博,MAB8705-KC,Mouse Anti-Dengue Complex, clone D3-2H2-9-21 (10mg) KC
下一件merck millipore产品：merck millipore,默克密理博,MAB10201,Anti-Hepatitis B Virus Surface Antigen Antibody, clone H25B10,MAB10201


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