merck millipore,默克密理博,341598,Fibroblast Growth Factor-2 Inhibitor, NSC37204

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Merck Millipore 默克密理愽

merck millipore,默克密理博,341598,Fibroblast Growth Factor-2 Inhibitor, NSC37204 - Calbiochem

经验配方
C₂₁H₁₄N₂Na₂O₉S₂

描述
概述	A small molecule, compound that is shown to compete with the binding domain of TSP-1 against angiogenic factor FGF-2 (IC₅₀ = 1.3 µM) in a dose-dependent manner and prevents the binding of FGF-2 to HSPG on endothelial cells (IC₅₀ = 24.0 ±6.9 µM), in vitro. It also demonstrates anti-growth properties in FGF-2-induced, but not serum-induced, endothelial cells (IC₅₀ = 20.3 µM ±5.9 µM). In CAM assays in vivo, where angiogenesis is induced by FGF-2 embedded in gelatin sponges, the presence of the small molecule (0.5 µg) reduces the mean number of blood vessels entering the sponge from 26 ±4 (FGF-2 alone) to 10 ±2 (FGF-2 + NSC37203).
产品目录编号	341598
品牌系列	Calbiochem®

参考
参考	Colombo, G., et al. 2010. J. Biol. Chem. 285, 8733.

生物信息
纯度	>95% by HPLC

理化信息
溶解度	DMSO

储存和货运信息
货运代码	Shipped with Blue Ice or with Dry Ice
毒性	Standard Handling
储存	-20°C
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

merck millipore,默克密理博,341598,Fibroblast Growth Factor-2 Inhibitor, NSC37204 - Calbiochem

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