merck millipore,默克密理愽
  • merck millipore,默克密理博,480450,NFF-2 - Calbiochem

  • merck millipore,默克密理博,480450,NFF-2 - Calbiochem

    产品名称：NFF-2 - Calbiochem
    产品型号：480450
    A quenched fluorescence substrate for MMPs.

    merck millipore,默克密理博,480450,NFF-2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,480450,NFF-2 - Calbiochem

    重要规格表
    描述
    概述 A quenched fluorescence substrate for MMPs. MMP-3 (stromelysin-1) hydrolyzes this substrate (kcat/Km = 5.9 x 104 M-1sec-1) at a rate 60 times faster than the hydrolysis by MMP-1 (interstitial collagenase). NFF-2 shows little discrimination between MMP-3, MMP-2 (gelatinase-A; kcat/Km = 5 x 104 M-1s-1), and MMP-9 (gelatinase-B; kcat/Km = 5.5 x 104 M-1s-1).
    Supplied as a trifluoroacetate salt.
    产品目录编号 480450
    品牌系列 Calbiochem®
    同义词 MCA-RPKPYANvaWMK(DNP)-NH₂
    参考
    参考 Nagase, H., et al. 1994. J. Biol. Chem. 269, 20952.
    产品信息
    具有ATP竞争性 N
    形式 Lyophilized yellow solid
    配方 Supplied as a trifluoroacetate salt.
    Hill配方 C₇₉H₁₀₅N₁₉O₁₉S
    化学配方 C₇₉H₁₀₅N₁₉O₁₉S
    Molar Mass 1656.2
    肽序列 MCA-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(DNP)-NH₂ (DNP = 2,4-dinitrophenyl; Nva = L-norvaline)
    可逆 N
    生物信息
    主靶 Matrix Metalloproteinases (MMPs)
    主靶IC50 kcat/Km = 5.9 x 104 M-1sec-1 as substrates for MMP-3 (stromelysin-1)
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 N
    最大排放 ~393 nm
    最大激励 ~325 nm
    溶解度 DMSO
    肽序列 MCA-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(DNP)-NH₂ (DNP = 2,4-dinitrophenyl; Nva = L-norvaline)
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    防潮 Protect from moisture
    无需冷冻 No
    特殊指南 Following initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

    merck millipore,默克密理博,480450,NFF-2 - Calbiochem

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