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经验配方 CAS号 C₁₆H₁₇N₃O₃S • MeSO₃H 182004-65-5 描述 概述 A cell-permeable isothiourea derivative that inhibits the influx/reverse mode of Na+/Ca2+ exchangers (NCX; IC50 = 4.3 µM, 4.7 µM, and 1.4 µM for NCX1,NCX2, and NCX3, respectively) and directly modulates Na+/Mg2+ exchange in a Ca2+-dependent manner. Reported to offer neuronal and cardioprotection. Also inhibits nicotinic acetylcholine receptors and NMDA receptor channels (IC50 < 10 µM). 产品目录编号 420336 品牌系列 Calbiochem®
同义词 2-(2-(4-(4-Nitrobenzyloxy)phenyl)ethyl)isothiourea, methane sulfonate, NMDA Antagonist III 参考 参考 Hobai, I.A., and O'Rourke, B. 2004. Expert Opin. Investig. Drugs 13, 653.
Uetani, T., et al. 2003. J. Biol. Chem. 278, 47491.
Iwamoto, T., et al. 2001. Mol. Pharmacol. 59, 524.
Pintado, A.J., et al. 2000. Br. J. Pharmacol. 130, 1893.
Sobolevsky, A.I., and Khodorov, B.I. 1999. Neuropharmacology 38, 1235.
Iwamoto, T., et al. 1996. J. Biol. Chem. 271, 22391.
Watano, T., et al. 1996. Br. J. Pharmacol. 119, 555.产品信息 CAS号 182004-65-5 具有ATP竞争性 N 形式 White crystalline solid Hill配方 C₁₆H₁₇N₃O₃S • MeSO₃H 化学配方 C₁₆H₁₇N₃O₃S • MeSO₃H Molar Mass 427.5 吸湿 Hygroscopic
可逆 N 结构配方图像 生物信息 主靶 Na+/Ca2+ exchangers 主靶IC50 4.3 µM, 4.7 µM, and 1.4 µM for NCX1,NCX2, and NCX3, respectively 纯度 ≥98% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO or H₂O 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Irritant
储存 +2°C to +8°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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