merck millipore,默克密理愽
  • merck millipore,默克密理博,14-773M,BTK (E41K) Protein, active, 250 µg

  • merck millipore,默克密理博,14-773M,BTK (E41K) Protein, active, 250 µg

    产品名称：BTK (E41K) Protein, active, 250 µg
    产品型号：14-773M
    Active, N-terminal His6-tagged, recombinant, full-length, human BTK, for use in Kinase Assays.

    merck millipore,默克密理博,14-773M,BTK (E41K) Protein, active, 250 µg

  • 产品介绍
  • merck millipore,默克密理博,14-773M,BTK (E41K) Protein, active, 250 µg

    描述
    产品目录编号 14-773M
    品牌系列 Upstate
    商名
    • Upstate
    描述 BTK (E41K) Protein, active, 250 µg
    概述 N-terminal His6-tagged, recombinant, full-length, human BTK
    背景信息 Specific mutations within the pleckstrin homology (PH) domain of BTK results in human X-linked agammaglobulinemia (XLA). The E41K substitution, identified through random mutagenesis, is a PH domain gain-of-function mutation that has been shown to be associated with increased membrane localization and tyrosine phosphorylation of BTK. Using animal models, this mutation has been shown to arrest the development of immature B cells and to act as a tumour suppressor in B-cell linker protein (BLNK/SLP-65)-deficient hosts. (Li, .et al., Immunity,(1995);2:451-460 and Baraldi, E., et al., Structure,(1999);7:449-460).
    应用
    应用 Active, N-terminal His6-tagged, recombinant, full-length, human BTK, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Expressed by baculovirus in Sf21 insect cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_000061
    基因符号
    • AGMX1
    • BTK
    • ATK
    • BPK
    蛋白靶 BTK
    纯化方法 Ni2+/NTA-agarose
    靶子系列 TK
    UniProt编号
    • P35991 (mouse)
    • Q06187
    产品使用声明
    质量保证 Routinely evaluated by phosphorylation of LKBtide.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Store -70°C. For maximum recovery of product, centrifuge original vial prior to removing the cap.

    Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into pre-chilled microcentrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70°C.
    包装信息
    数量 250 µg
    包装 Also available in 10 μg size (cat#14-773) and in bulk (cat# 14-773-K).

    merck millipore,默克密理博,14-773M,BTK (E41K) Protein, active, 250 µg

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