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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MAB10009 描述 Anti-IDO Antibody, clone 1F8.2 Alternate Names - IDO1
- Indoleamine-pyrrole 2,3-dioxygenase
- indole 2,3-dioxygenase
- indoleamine 2,3-dioxygenase 1
- indoleamine-pyrrole 2,3 dioxygenase
背景信息 Indoleamine 2,3-dioxygenase (IDO) is an enzyme that is responsible for converting tryptophan to kynurenines. IDO is expressed by a wide variety of tissues and IDO can be upregulated by interferon gamma. IDO modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. IDO may be involved in the
suppression of the immune response to tumours and blocking the IDO pathway may be a potential target for immunotherapy.产品信息 格式 Purified 控制 - HeLa cell lysate treated with interferon gamma.
演示 Mouse monoclonal in buffer containing 0.1 M Tris-glycine, pH 7.4, 150 mM NaCl and 0.05% sodium azide. 应用 应用 Anti-IDO Antibody, clone 1F8.2 is an antibody against IDO for use in WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
生物信息 免疫原品种 GST-tagged recombinant protein of full-length human IDO. 克隆 1F8.2 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody recognizes IDO. 同种型 IgG1κ 品种反应性 Human Species Reactivity Note Proven to react with human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_002155.1
基因符号 - INDO
- CD107B
- EC 1.13.11.52
- IDO
纯化方法 Protein G purfied UniProt编号 - P14902
UniProt汇总 FUNCTION: Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen.
CATALYTIC ACTIVITY: D-tryptophan + O2 = N-formyl-D-kynurenine.
L-tryptophan + O2 = N-formyl-L-kynurenine.
COFACTOR: Binds 1 heme group per subunit.
INDUCTION: By interferon gamma.
SEQUENCE SIMILARITIES: Belongs to the indoleamine 2,3-dioxygenase family.产品使用声明 质量保证 Evaluated by Western Blot in HeLa cell lysate.
Western Blot Analysis: 0.1 µg/mL dilution of this antibody detected IDO on 15 µg of HeLa cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8°C for 1 year from date of receipt. 包装信息 数量 100 µg
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