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merck millipore,默克密理博,496265,Oncrasin-1 - CAS 75629-57-1 - Calbiochem
产品名称：Oncrasin-1 - CAS 75629-57-1 - Calbiochem
产品型号：496265
A cell-permeable indolecarboxaldehyde compound that selectively induces apoptosis in cells harboring mutant K-Ras both in vitro and in vivo.
merck millipore,默克密理博,496265,Oncrasin-1 - CAS 75629-57-1 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₆H₁₂ClNO 75629-57-1 描述 概述 A cell-permeable indolecarboxaldehyde compound that selectively induces apoptosis in cells harboring mutant K-Ras both in vitro (IC50 = 0.11, 0.25, 1.0, 1.58, and 4.81 µM in H2887, H460, H2122, A549, and T29Kt1 cultures, respectively) and in vivo (75% suppression of H460-derived tumor growth in mice; 100 mg/kg via daily i.p.), while exhibiting little or much reduced potency toward cells with wild-type Ras or mutant N-Ras (IC50 ≥31 µM). Oncrasin-1 treatment is shown to induce PKCι aggregation with splicing factors in the nucleus and dissociation between PKCι and CDK9/Cyclin T1 in K-Ras mutant cultures, resulting in decreased RNA polymerase II phosphorylation and a suppression of RNA processing in general. Oncrasin-1-induced cell death requires the presence of both mutant K-Ras and PKCι, siRNA-mediated knockdown of either enzyme is demonstrated to abolish its cytotoxicity in H460 and T29Kt1 cultures. 产品目录编号 496265 品牌系列 Calbiochem®
同义词 1-((4-Chlorobenzyl)-1H-indole-3-carboxaldehyde, Oncogenic Ras Tumor-Inhibiting compound 1 参考 参考 Guo, W., et al. 2009. Mol. Cancer Ther. 8, 441.
Guo, W., et al. 2008. Cancer Res. 68, 7403.产品信息 CAS号 75629-57-1 形式 Off-white solid Hill配方 C₁₆H₁₂ClNO 化学配方 C₁₆H₁₂ClNO Molar Mass 269.7 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 安全信息 R相 R: 36/38
Irritating to eyes and skin.S相 S: 26-36-45
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).储存和货运信息 货运代码 Ambient Temperature Only
毒性 Irritant
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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下一件merck millipore产品：merck millipore,默克密理博,14-926M,IKKε Protein, active, 250 µg
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