merck millipore,默克密理博,HTS156RTA,Ready-to-Assay™ MC1 Melanocortin Receptor Frozen Cells

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merck millipore,默克密理博,HTS156RTA,Ready-to-Assay™ MC1 Melanocortin Receptor Frozen Cells
产品名称：Ready-to-Assay™ MC1 Melanocortin Receptor Frozen Cells
产品型号：HTS156RTA

merck millipore,默克密理博,HTS156RTA,Ready-to-Assay™ MC1 Melanocortin Receptor Frozen Cells

产品介绍

merck millipore,默克密理博,HTS156RTA,Ready-to-Assay™ MC1 Melanocortin Receptor Frozen Cells

重要规格表

应用说明	品种	宿主细胞	蛋白靶
cAMP accumulation	Human	Chem-1	MC1

描述
产品目录编号	HTS156RTA
商名	Ready-to-Assay
描述	Ready-to-Assay™ MC1 Melanocortin Receptor Frozen Cells
背景信息	EMD Millipore’s Ready-to-Assay GPCR frozen cells are designed for simple, rapid calcium assays with no requirement for intensive cell culturing. EMD Millipore has optimized the freezing conditions to provide cells with high viability and functionality post-thaw. The user simply thaws the cells and resuspends them in media, dispenses cell suspension into assay plates and, following over night recovery, assays for calcium response. The melanocortin-1 receptor (MC1) is a member of the G-protein-coupled receptor family of proteins that is responsible for regulating skin and hair color. The MC1 receptor is regulated by the physiological agonists alpha-melanocyte-stimulating hormone (α-MSH) and adrenocorticotropic hormone (ACTH), and antagonist agouti signaling protein (ASP) (Rouzud et al., 2005). In 1995 a landmark study demonstrated that over 80% of humans with red hair or fair skin have a dysfunctional variant of the MC1 gene (Valverde et al., 1995). MC1 is, therefore, a major determinant of sun sensitivity and genetic risk factor for melanoma and non-melanoma skin cancer. EMD Millipore’s cloned human MC1 receptor-expressing ChemiScreen cells were constructed by stable transfection of Chem-1 cells with the MC-1 receptor. These stability-tested cells are ready for cAMP accumulation assays for agonists, antagonists and modulators at the MC1 receptor.

产品信息
部件	Fifty (50) mL of Media Component. Pack contains 2 vials of mycoplasma-free cells, 1 ml per vial.
检测方法	Fluorescent

应用
应用说明	cAMP accumulation

生物信息
品种	Human
Entrez基因编号	NM_002386
GPCR类别	A
宿主细胞	Chem-1
蛋白靶	MC1
靶子系列	Melanocortin
细胞系类型	Ready-to-Assay

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial This product contains genetically modified organisms (GMO). Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively. This legislation obliges Merck-Millipore to request certain information about you and the establishment where the GMOs are being handled.

产品使用声明

使用声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial
This product contains genetically modified organisms (GMO). Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively. This legislation obliges Merck-Millipore to request certain information about you and the establishment where the GMOs are being handled.