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merck millipore,默克密理博,FCIM025164,FlowCellect™ Human NK Cell Characterization Kit
产品名称：FlowCellect™ Human NK Cell Characterization Kit
产品型号：FCIM025164
This FlowCellect Human NK cell characterization Kit includes three directly conjugated antibodies, Anti-CD3-APC, Anti-CD56-PE & Anti-CD16 FITC in flow cytometry applications.
merck millipore,默克密理博,FCIM025164,FlowCellect™ Human NK Cell Characterization Kit
- 产品介绍
描述 产品目录编号 FCIM025164 商名 - FlowCellect
描述 FlowCellect™ Human NK Cell Characterization Kit 概述 Millipore’s FlowCellect™ Human NK cell characterization kit includes three directly conjugated antibodies, Anti-CD3-APC, Anti-CD56-PE, and Anti-CD16 FITC. This three color kit is designed to characterize NK within mixed cell populations. The antibodies provided have been carefully titrated to ensure the ability to accurately measure the expression of all markers simultaneously. Sufficient reagents are provided to perform 25 three-color tests. Detailed assay instructions are included to assist in analysis and to ensure the correct cell concentration is obtained during acquisition of sample data. Alternate Names - Flow Cellect
背景信息 Natural Killer (NK) cells are a subset of lymphocytes that serve in innate immunity. These cells are defined phenotypically by the presence of surface neural cell adhesion molecule (NCAM) or CD56, and the absence of the T-cell coreceptor CD3, with a large percentage of these cells also expressing the Fc gamma receptor molecule or CD16. Natural Killer cells are larger in size than their B and T-lymphocyte counterparts.
The activation of NK cells is a two-signal mechanism, consisting of the interplay between a positive and negative signal. The positive signal takes the form of an activation receptor which, when bound by corresponding ligands on the target cells, will trigger activity, while the presence of the major histocompatibility complex I (MHC I) molecule on the surface of the target cell serves as the negative signal. During exposure to bacterial and viral pathogens, the downregulation of surface MHC I on infected cells causes the removal of the inhibitory block on NK function, which when combined with ligation of the activation receptor, results in activation of NK effector functions.
Natural Killer cells can perform two main immune functions upon activation. The more common one is the direct lysing of target cells through the release of pro-apoptotic molecules perforin and granzyme. Meanwhile, a small subset of NK cells can also serve in an immunoregulatory role, through the secretion of various cytokines such as interferon gamma (IFN-g) to activate the function of other innate immunity cells such as macrophages.产品信息 部件 - 6. 5X Assay Buffer: (Part No. CS202124) One bottle containing 55 mL.
- 1. 20X Anti-CD3-APC: (Part No. CS206532) One vial containing 150 µL.
- 2. 20X Anti-CD16-FITC: (Part No. CS206533) One vial containing 150 µL.
- 3. 20X Anti-CD56-PE: (Part No. CS206534) One vial containing 150 µL.
- 4. Fixation Buffer: (Part No. CS202122) One bottle containing 13 mL.
- 5. 10X Wash Buffer: (Part No. CS202123) One bottle containing 13 mL.
检测方法 Fluorescent 应用 应用 This FlowCellect Human NK cell characterization Kit includes three directly conjugated antibodies, Anti-CD3-APC, Anti-CD56-PE & Anti-CD16 FITC in flow cytometry applications. 主要应用 - Flow Cytometry
生物信息 宿主 Mouse 品种反应性 Human 抗体类型 Monoclonal Antibody 产品使用声明 质量保证 Lot to lot in-process testing on all kit components 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 4-8°C for antibodies and buffers 包装信息 数量 25 Tests / Kit
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