merck millipore,默克密理愽
  • merck millipore,默克密理博,07-156,Anti-phospho-Caldesmon (Ser789) Antibody

  • merck millipore,默克密理博,07-156,Anti-phospho-Caldesmon (Ser789) Antibody

    产品名称：Anti-phospho-Caldesmon (Ser789) Antibody
    产品型号：07-156
    Detect phospho-Caldesmon (Ser789) using this Anti-phospho-Caldesmon (Ser789) Antibody validated for use in EA & WB.

    merck millipore,默克密理博,07-156,Anti-phospho-Caldesmon (Ser789) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-156,Anti-phospho-Caldesmon (Ser789) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Po, Ca, FtWBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 07-156
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-Caldesmon (Ser789) Antibody
    产品信息
    格式 Purified
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
    应用
    应用 Detect phospho-Caldesmon (Ser789) using this Anti-phospho-Caldesmon (Ser789) Antibody validated for use in EA & WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 peptide corresponding to amino acids 782-793 (C-QSVDKVT[pS]PTKV) of human Caldesmon
    宿主 Rabbit
    特异性 Caldesmon phosphorylated on serine 789
    同种型 IgG
    品种反应性 PigCanineFerret
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_033140
    Entrez基因汇总 This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
    基因符号
    • H-CAD
    • CALD1
    • Caldesmon
    • CAD
    • CDM
    • L-CAD
    • MGC21352
    • NAG22
    修改
    • Phosphorylation
    纯化方法 Protein A chromatography
    UniProt编号
    • Q05682
    UniProt汇总 FUNCTION: SwissProt: Q05682 # Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping.
    SIZE: 793 amino acids; 93250 Da
    SUBCELLULAR LOCATION: Note=On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle) (By similarity).
    TISSUE SPECIFICITY: High-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular- weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart.
    DOMAIN: SwissProt: Q05682 The N-terminal part seems to be a myosin/calmodulin- binding domain, and the C-terminal a tropomyosin/actin/calmodulin- binding domain. These two domains are separated by a central helical region in the smooth-muscle form.
    PTM: In non-muscle cells, phosphorylation by CDC2 during mitosis causes caldesmon to dissociate from microfilaments. Phosphorylation reduces caldesmon binding to actin, myosin, and calmodulin as well as its inhibition of actomyosin ATPase activity. Phosphorylation also occurs in both quiescent and dividing smooth muscle cells with similar effects on the interaction with actin and calmodulin and on microfilaments reorganization (By similarity).
    SIMILARITY: Belongs to the caldesmon family.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on a RIPA lysate of EGF stimulated human A431 cells; pretreatment of blots with lambda phosphatase prior to incubation abolished the detection of Caldesmon
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,07-156,Anti-phospho-Caldesmon (Ser789) Antibody

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