merck millipore,默克密理博,GF134,Pigment Epithelium Derived Factor Protein, Recombinant human

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Merck Millipore 默克密理愽

主要应用	品种	来源	纯度
PC	Human	Stable BHK (baby hamster kidney) cell transfectants	PEDF is purified via affinity purification from culture supernatants; Greater than 95% pure by SDS-PAGE analysis. Product may be rendered sterile by 0.22-micron filtration.

描述
产品目录编号	GF134
品牌系列	Chemicon®
商名	Chemicon
描述	Pigment Epithelium Derived Factor Protein, Recombinant human
概述	Pigment epithelium-derived factor (PEDF) was first identified as a 50 kDa secreted protein in conditioned medium from cultured fetal human retinal pigment epithelium (RPE) cells (Tombran-Tink et al., 1991). PEDF has been shown to have neurotrophic activity in the retina in vivo (Cayouette et al., 1999). PEDF is also a neurotrophic and neuroprotective factor in other systems, including cultured cerebellar granule cells, primary hippocampal neurons, spinal cord motor neurons and amphibian photoreceptors cultured in the absence of RPE cells (Karakousis, et al., 2001). The binding of PEDF to retinoblastoma and cerebellar granule cells may be receptor-mediated. Recently, PEDF was shown to be a potent inhibitor of angiogenesis in endothelial cell cultures and in rat cornea and retina in vivo (Dawson et al., 2001; Stellmach et al., 2001).
Alternate Names	PEDF

产品信息
演示	Provided liquid in 20 mM sodium phosphate, pH 6.4, 0.2 M sodium chloride, and 1 mM DTT. Product has been sterile filtered to 0.22-micron.

应用
应用	The Pigment epithelium-derived factor (PEDF) was first identified as a 50 kDa secreted protein in conditioned medium from cultured fetal human retinal pigment epithelium (RPE) cells (Tombran-Tink et al., 1991).
主要应用	Positive Control

生物信息
纯度	PEDF is purified via affinity purification from culture supernatants; Greater than 95% pure by SDS-PAGE analysis. Product may be rendered sterile by 0.22-micron filtration.
来源	Stable BHK (baby hamster kidney) cell transfectants
品种	Human
Entrez基因编号	NM_002615.4
基因符号	PIG35 SERPINF1 Serpin-F1 EPC-1 PEDF
UniProt编号	P36955
UniProt汇总	FUNCTION: SwissProt: P36955 # Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. SIZE: 418 amino acids; 46342 Da SUBCELLULAR LOCATION: Secreted. Melanosome. Note=Enriched in stage I melanosomes. TISSUE SPECIFICITY: Retinal pigment epithelial cells and blood plasma. DEVELOPMENTAL STAGE: Expressed in quiescent cells. DOMAIN: SwissProt: P36955 The N-terminal (AA 44-121) exhibits neurite outgrowth- inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity. PTM: The N-terminus is blocked. SIMILARITY: Belongs to the serpin family.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain frozen at -70°C in undiluted aliquots for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles. .

包装信息
数量	10 µg

merck millipore,默克密理博,GF134,Pigment Epithelium Derived Factor Protein, Recombinant human

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