merck millipore,默克密理愽
  • merck millipore,默克密理博,05-382,Anti-Na+/K+ ATPase β-1 Antibody, clone C464.8

  • merck millipore,默克密理博,05-382,Anti-Na+/K+ ATPase β-1 Antibody, clone C464.8

    产品名称：Anti-Na+/K+ ATPase β-1 Antibody, clone C464.8
    产品型号：05-382
    This Anti-Na+/K+ ATPase β-1 Antibody, clone C464.8 is validated for use in IH, WB for the detection of Na+/K+ ATPase β-1.

    merck millipore,默克密理博,05-382,Anti-Na+/K+ ATPase β-1 Antibody, clone C464.8

  • 产品介绍
  • merck millipore,默克密理博,05-382,Anti-Na+/K+ ATPase β-1 Antibody, clone C464.8

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Rb, B, Ca, H, RWB, IHCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-382
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-Na+/K+ ATPase β-1 Antibody, clone C464.8
    概述 Clone C464.8 is also referred to as clone 8A
    产品信息
    格式 Purified
    控制
    • Expressed in most tissue, including brain, heart and kidney
    演示 Protein G Purified immunoglobulin in Protein G Purified immunoglobulin in PBS with 0.05% sodium azide before the addition of glycerol to 30%
    应用
    应用 This Anti-Na+/K+ ATPase β-1 Antibody, clone C464.8 is validated for use in IH, WB for the detection of Na+/K+ ATPase β-1.
    主要应用
    • Western Blotting
    • Immunohistochemistry
    生物信息
    免疫原品种 Purified Na+/K+ ATPase isolated from membrane fractions of rabbit kidney outer medulla.
    克隆 C464.8
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Recognizes the β-1 subunit isoform of Na+/K+.
    同种型 IgG2aκ
    品种反应性 RabbitBovineCanineHumanRat
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_001677
    Entrez基因汇总 The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit.
    基因符号
    • Na
    • ATP1A3
    • MGC13276
    • RDP
    • IIIsubunit).
    • DYT12
    • +K
    纯化方法 Protein G purfied
    UniProt编号
    • P13637
    UniProt汇总 FUNCTION: SwissProt: P13637 # This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
    SIZE: 1013 amino acids; 111749 Da
    SUBUNIT: Composed of three subunits: alpha (catalytic), beta and gamma.
    SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
    DISEASE: SwissProt: P13637 # Defects in ATP1A3 are the cause of dystonia-12 (DYT12) [MIM:128235]; also known as rapid-onset dystonia parkinsonism (RDP). DYT12 is an autosomal dominant form of dystonia- parkinsonism characterized by an unusually rapid evolution of signs and symptoms. Affected persons develop dystonia and parkinsonism between 14 and 45 years of age. The sudden onset of symptoms over hours to a few weeks, often associated with physical or emotional stress, suggests a trigger initiating a nervous system insult resulting in permanent neurologic disability.
    SIMILARITY: SwissProt: P13637 ## Belongs to the cation transport ATPase (P-type) family. Type IIC subfamily.
    产品使用声明
    质量保证 routinely evaluated in immunoblot on rat brain, rat heart or rat kidney microsomal preparations
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 200 µg

    merck millipore,默克密理博,05-382,Anti-Na+/K+ ATPase β-1 Antibody, clone C464.8

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