merck millipore,默克密理愽
  • merck millipore,默克密理博,AB1537,Anti-Dopamine β Hydroxylase Antibody, CT

  • merck millipore,默克密理博,AB1537,Anti-Dopamine β Hydroxylase Antibody, CT

    产品名称：Anti-Dopamine β Hydroxylase Antibody, CT
    产品型号：AB1537
    This Anti-Dopamine β Hydroxylase Antibody, C-terminus is validated for use in WB, IH for the detection of Dopamine β Hydroxylase.

    merck millipore,默克密理博,AB1537,Anti-Dopamine β Hydroxylase Antibody, CT

  • 产品介绍
  • merck millipore,默克密理博,AB1537,Anti-Dopamine β Hydroxylase Antibody, CT

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Mk, HIHC, WBShAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB1537
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Dopamine β Hydroxylase Antibody, CT
    Alternate Names
    • DBH
    产品信息
    格式 Affinity Purified
    演示 Affinity purified immunoglobulin. Liquid in 10 mM HEPES, pH 7.5, 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.
    应用
    应用 This Anti-Dopamine β Hydroxylase Antibody, C-terminus is validated for use in WB, IH for the detection of Dopamine β Hydroxylase.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Immunoblotting: 1:250-1:1,000 on human, monkey and bovine adrenal medulla.

    Immunohistochemistry: 1:250-1:1,000, staining was evaluated in the locus coeruleus of formaldehyde-fixed, cryopreserved human and monkey brain. Showed strong staining on both human and monkey.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Synthetic peptide, CPTSQGRSPAGPTVVSI-amide, from C-terminal region of human (DbetaH).
    表位 C-terminus
    宿主 Sheep
    特异性 Dopamine Beta Hydroxylase (DbetaH) C-terminal. By immunoblot the antibody specifically reacts with a single (or double) band(s) of M.W. »70-75,000 in samples of SDS-solubilized, DTT-reduced human adrenal medulla subjected to SDS-PAGE.
    品种反应性 MonkeyHuman
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_000787.3
    Entrez基因汇总 The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide.
    基因符号
    • EC 1.14.17.1 [Contains: Soluble dopamine beta-hydroxylase].
    • DBH
    • DBM
    UniProt编号
    • P09172
    UniProt汇总 FUNCTION: SwissProt: P09172 # Conversion of dopamine to noradrenaline.
    COFACTOR: Binds 1 PQQ per subunit. & Binds 2 copper ions per subunit.
    SIZE: 617 amino acids; 69065 Da
    SUBUNIT: Homotetramer composed of two non-covalently bound disulfide-linked dimers.
    SUBCELLULAR LOCATION: Soluble dopamine beta-hydroxylase: Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen. & Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type II membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single- pass type II membrane protein (Potential).
    DISEASE: SwissProt: P09172 # Defects in DBH are the cause of DBH deficiency [MIM:223360]; also called norepinephrine deficiency or noradrenaline deficiency. This disorder is characterized by profound deficits in autonomic and cardiovascular function, but apparently only subtle signs, if any, of central nervous system dysfunction.
    SIMILARITY: SwissProt: P09172 ## Belongs to the copper type II ascorbate-dependent monooxygenase family. & Contains 1 DOMON domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20 to -70°C in undiluted aliquots for up to six months. Avoid repeated freeze-thaw cycles.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB1537,Anti-Dopamine β Hydroxylase Antibody, CT

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