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merck millipore,默克密理博,GF027,Tumor Necrosis Factor-α Protein, Recombinant mouse
产品名称：Tumor Necrosis Factor-α Protein, Recombinant mouse
产品型号：GF027
Tumor Necrosis Factor-a (TNF-alpha) is a potent lymphoid factor which exerts cytotoxic effects on a wide range of tumor cells & certain other target cells.
merck millipore,默克密理博,GF027,Tumor Necrosis Factor-α Protein, Recombinant mouse
- 产品介绍
重要规格表
主要应用 品种 来源 纯度 CULT Mouse E.coli Greater than 98% by SDS-PAGE analysis and HPLC ana 描述 产品目录编号 GF027 品牌系列 Chemicon®
商名 - Chemicon
描述 Tumor Necrosis Factor-α Protein, Recombinant mouse 概述 Tumor Necrosis Factor-a (TNF-alpha) is a potent lymphoid factor which exerts cytotoxic effects on a wide range of tumor cells and certain other target cells. Mouse TNF-alpha is a 17.5 kDa protein containing 156 amino acid residues. Alternate Names - TNF-alpha
产品信息 演示 The sterile filtered solution was lyophilized from 5 mM Tris, pH 8.0. For reconstitution, we recommend a quick spin followed by reconstitution in sterile water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers. 应用 应用 Tumor Necrosis Factor-a (TNF-alpha) is a potent lymphoid factor which exerts cytotoxic effects on a wide range of tumor cells & certain other target cells. 主要应用 - Cell Culture
应用说明 For most in vitro applications, mouse TNF-alpha exerts its biological activity in the concentration range of 0.05 to 20.0 ng/mL. Responding cells are (partial list): Tumor cells, certain other cells. 生物信息 纯度 Greater than 98% by SDS-PAGE analysis and HPLC ana 来源 E.coli 品种 Mouse 特异活性 The ED(50) as determined by the cytolysis of L929 cells in the presence of actinomycin-D is <= 0.1 ng/mL, corresponding to a specific activity of >= 1x10(E7) units/mg. Entrez基因汇总 This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. UniProt编号 - P06804
- P01375
UniProt汇总 FUNCTION: SwissProt: P01375 # Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
SIZE: 233 amino acids; 25644 Da
SUBUNIT: Homotrimer.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. & Tumor necrosis factor, soluble form: Secreted.
PTM: The soluble form derives from the membrane form by proteolytic processing. & The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
DISEASE: SwissProt: P01375 # Cachexia accompanies a variety of diseases, including cancer and infection, and is characterized by general ill health and malnutrition. & Genetic variations in TNF are associated with susceptibility to psoriatic arthritis [MIM:607507]. Psoriasis is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin lesions that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. Psoriatic arthritis has been defined as an inflammatory arthritis usually without any rheumatoid factor in serum (seronegative arthritis) associated with psoriasis. & Genetic variations in TNF are associated with susceptibility to hepatitis B virus infection (HBV infection) [MIM:610424]. Approximately one third of all cases of cirrhosis and half of all cases of hepatocellular carcinoma can be attributed to chronic HBV infection. HBV infection may result in subclinical or asymptomatic infection, acute self-limited hepatitis, or fulminant hepatitis requiring liver transplantation.
SIMILARITY: SwissProt: P01375 ## Belongs to the tumor necrosis factor family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 The lyophilized powder, though stable at room temperature, is best stored desiccated below 0°C. Reconstitute with sterile water to a concentration of 100 ng/uL. This solution can be diluted into other buffered solutions. Reconstituted mouse TNF-alpha should be stored in undiluted aliquots at -20°C for up to 6 months. 包装信息 数量 20 µg
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