merck millipore,默克密理愽
  • merck millipore,默克密理博,AB9834,Anti-Tyrosine Kinase Receptor C Antibody

  • merck millipore,默克密理博,AB9834,Anti-Tyrosine Kinase Receptor C Antibody

    产品名称：Anti-Tyrosine Kinase Receptor C Antibody
    产品型号：AB9834
    Tyrosine Kinase Receptor C is an antibody targeting the Tyrosine Kinase Receptor C protein, validated for use in IHC.

    merck millipore,默克密理博,AB9834,Anti-Tyrosine Kinase Receptor C Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB9834,Anti-Tyrosine Kinase Receptor C Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MIHCRbSerumPolyclonal Antibody
    描述
    产品目录编号 AB9834
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Tyrosine Kinase Receptor C Antibody
    Alternate Names
    • trkC
    背景信息 The mammalian Trk family of receptor tyrosine kinases consists of three principle transmembrane proteins. The receptors can be activated by one or more of four neurotrophins - NGF, BDNF, NT3 and NT4. Each of the four members of the TrkC family, expressed by alternative splicing, serves as a receptor for NT-3, with some evidence for endogenous activation also by NGF. These neurotrophins regulate biological responses such as cell survival, proliferation and differentiation in normal and neoplastic neuronal cells primarily, but several other cell types have been shown to express the TrkC receptor. The receptor has also been demonstrated on many tumors of neuronal origin.
    产品信息
    格式 Serum
    演示 Lyophilized. Reconstitute with 50 μL of sterile distilled water. Centrifuge to remove any insoluble material. Contains no preservative.
    应用
    应用 Tyrosine Kinase Receptor C is an antibody targeting the Tyrosine Kinase Receptor C protein, validated for use in IHC.
    主要应用
    • Immunohistochemistry
    应用说明 Results of immunohistochemistry in the dorsal root ganglion have been described by Chen. C., et al., Neurochemical Research (1996) 21(7):809-814..
    生物信息
    免疫原品种 Extracellular domain of the recombinant human receptor expressed in mammalian cells.
    宿主 Rabbit
    特异性 trkC [Neurotrophin-3 growth factor receptor; tyrosine kinase receptor C]. All four forms of the TrkC receptor are expected to be detected by this antibody. The immunogen sequence was chosen to avoid cross reactivity with trkA or trkB.
    品种反应性 RatHumanMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_002530.2
    • NM_001007156.1
    • NM_001012338.1
    Entrez基因汇总 This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.
    基因符号
    • EC 2.7.10.1
    • NTRK3
    • TRKC
    • gp145(trkC)
    • Trk-C
    • GP145-TrkC
    纯化方法 Serum
    UniProt编号
    • Q16288
    UniProt汇总 FUNCTION: SwissProt: Q16288 # Receptor for neurotrophin-3 (NT-3). This is a tyrosine- protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.
    SIZE: 839 amino acids; 94428 Da
    SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 (By similarity).
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    TISSUE SPECIFICITY: Widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain.
    PTM: Ligand-mediated auto-phosphorylation.
    SIMILARITY: SwissProt: Q16288 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. & Contains 2 Ig-like C2-type (immunoglobulin-like) domains. & Contains 2 LRR (leucine-rich) repeats. & Contains 1 protein kinase domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain lyophilized material frozen at -20°C to -70°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1, ACS or better grade) can be added for additional stability.
    包装信息
    数量 50 µL

    merck millipore,默克密理博,AB9834,Anti-Tyrosine Kinase Receptor C Antibody

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