merck millipore,默克密理愽
  • merck millipore,默克密理博,05-507,Anti-Cdc25C Antibody, clone TC-15

  • merck millipore,默克密理博,05-507,Anti-Cdc25C Antibody, clone TC-15

    产品名称：Anti-Cdc25C Antibody, clone TC-15
    产品型号：05-507
    Detect Cdc25C with Anti-Cdc25C Antibody, clone TC-15 (Mouse Monoclonal Antibody), that has been shown to work in IP, WB, ICC.

    merck millipore,默克密理博,05-507,Anti-Cdc25C Antibody, clone TC-15

  • 产品介绍
  • merck millipore,默克密理博,05-507,Anti-Cdc25C Antibody, clone TC-15

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HICC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-507
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-Cdc25C Antibody, clone TC-15
    背景信息 The activity of cyclin-dependent kinases is regulated by their phosphorylation status, which is controlled by the antagonistic action of CDC25 phosphatases. Three CDC25 genes are present in human cells: CDC25A, CDC25B and CDC25C. CDC25C is a ~56 kDa dual specific protein phosphatase that controls entry into mitosis by regulating the dephosphorylation of the Cdk1/cyclin B complex. Phosphorylation of Cdc25C creates a binding site for 14-3-3 protein which inhibits Cdc25C. This prevents activation of the Cdk1/cyclin B complex and prevents mitotic entry. Cdc25C is phosphorylated by checkpoint kinases throughout interphase but becomes dephosphorylated during mitosis. Cdc25C is also regulated by p53 via a p53 response element in its promoter, and it is predominantly expressed in the G2 phase of the cell cycle.
    产品信息
    格式 Purified
    控制
    • HeLa nuclear extract
    演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
    应用
    应用 Detect Cdc25C with Anti-Cdc25C Antibody, clone TC-15 (Mouse Monoclonal Antibody), that has been shown to work in IP, WB, ICC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    生物信息
    免疫原品种 GST fusion-protein corresponding to residues 1-258 of human cdc25C. Epitope mapped to residues 222-246.
    克隆 clone TC-15
    宿主 Mouse
    特异性 cdc25C
    同种型 IgG1κ
    品种反应性 MouseHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_001790
    Entrez基因汇总 This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.
    基因符号
    • CDC25
    • CDC25C
    纯化方法 Protein G chromatography
    UniProt编号
    • P30307
    UniProt汇总 FUNCTION: SwissProt: P30307 # Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDC2 and activate its kinase activity.
    SIZE: 473 amino acids; 53365 Da
    SUBUNIT: Interacts with HIV-1 Vpr, thereby inactivating CDC25C phosphatase activity.
    SUBCELLULAR LOCATION: Nucleus.
    DEVELOPMENTAL STAGE: Expressed predominantly in G2 phase.
    PTM: Phosphorylated by CHK1 on Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase.
    SIMILARITY: SwissProt: P30307 ## Belongs to the MPI phosphatase family. & Contains 1 rhodanese domain.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on HeLa nuclear extract
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 100 µg

    merck millipore,默克密理博,05-507,Anti-Cdc25C Antibody, clone TC-15

上一件merck millipore产品：merck millipore,默克密理博,AB9834,Anti-Tyrosine Kinase Receptor C Antibody
下一件merck millipore产品：merck millipore,默克密理博,ABN282,Anti-PTGES2 Antibody


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