merck millipore,默克密理博,HTS112RTA,Ready-to-Assay™ Glucagon Receptor Frozen Cells

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merck millipore,默克密理博,HTS112RTA,Ready-to-Assay™ Glucagon Receptor Frozen Cells
产品名称：Ready-to-Assay™ Glucagon Receptor Frozen Cells
产品型号：HTS112RTA
Human glucagon / GCG GPCR frozen cells for Calcium flux Assays, ligand binding FLIPR Assays.

merck millipore,默克密理博,HTS112RTA,Ready-to-Assay™ Glucagon Receptor Frozen Cells

产品介绍

merck millipore,默克密理博,HTS112RTA,Ready-to-Assay™ Glucagon Receptor Frozen Cells

重要规格表

应用说明	品种	宿主细胞	蛋白靶
Calcium flux assay, ligand binding assays	Human	Chem-1	glucagon / GCG

描述
产品目录编号	HTS112RTA
商名	Ready-to-Assay
描述	Ready-to-Assay™ Glucagon Receptor Frozen Cells
背景信息	Millipore’s Ready-to-Assay GPCR frozen cells are designed for simple, rapid calcium assays with no requirement for intensive cell culturing. Millipore has optimized the freezing conditions to provide cells with high viability and functionality post-thaw. The user simply thaws the cells and resuspends them in media, dispenses cell suspension into assay plates and, following over night recovery, assays for calcium response. Glucagon is a 29-amino acid peptide that stimulates glycogenolysis and gluconeogenesis in the liver to increase blood glucose. The receptor for glucagon is a class 2 (or class B) GPCR that signals through Gs to stimulate cAMP production (Mayo et al., 2003). Mice lacking the glucagon receptor have mild hypoglycemia after fasting, and exhibit hyperplasia of pancreatic alpha-cells (Gelling et al., 2003). Because of its role in promoting hyperglycemia, the glucagon receptor presents a potential target for treatment of diabetes. Chemicon's cloned human Glucagon Receptor-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant Glucagon Receptor expression on the cell surface and contains high levels of the promiscuous G protein Galpha15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between the Glucagon Receptor and its ligands.

产品信息
部件	Fifty (50) mL of Media Component. Pack contains 2 vials of mycoplasma-free cells, 1 ml per vial.

应用
应用	Human glucagon / GCG GPCR frozen cells for Calcium flux Assays, ligand binding FLIPR Assays.
应用说明	Calcium flux assay, ligand binding assays

生物信息
品种	Human
GPCR类别	B
宿主细胞	Chem-1
蛋白靶	glucagon / GCG
靶子系列	Glucagon
细胞系类型	Ready-to-Assay

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. This product contains genetically modified organisms (GMO). Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively. This legislation obliges Merck-Millipore to request certain information about you and the establishment where the GMOs are being handled.

产品使用声明

使用声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
This product contains genetically modified organisms (GMO). Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively. This legislation obliges Merck-Millipore to request certain information about you and the establishment where the GMOs are being handled.