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merck millipore,默克密理博,537076,Proprotein Convertase Inhibitor - Calbiochem
产品名称：Proprotein Convertase Inhibitor - Calbiochem
产品型号：537076
The Proprotein Convertase Inhibitor controls the biological activity of Proprotein Convertase. This small molecule/inhibitor is primarily used for Cell Signaling applications.
merck millipore,默克密理博,537076,Proprotein Convertase Inhibitor - Calbiochem
- 产品介绍
重要规格表
经验配方 C₃₅H₅₅N₁₅O₄ 描述 概述 A cell-permeable tripeptide derivative containing an Arg-X-Arg motive that acts as a highly potent and reversible furin inhibitor (Ki = 16 pM). Also shown to inhibit several other pro-protein convertases, such as PC1/3, PC4, PAEC4, PC5/6 with almost similar potency, but does not affect PC2, PC7, and trypsin-like serine proteases in any significant manner. Acts as a very weak inhibitor of plasmin (Ki = 7.3 µM). Exhibits greater stability in cells. Shown to block hemagglutinin cleavage (40% at 1 µM) and fowl plague virus (FPV) viral propagation in a dose-dependent manner. Exhibits minimal toxicity even at high concentrations (25-50 µM) and protects human epidermoid carcinoma (HEp-2) cells from toxic effects of Shiga toxin. 产品目录编号 537076 品牌系列 Calbiochem®
同义词 Furin-like Proprotein Convertase Inhibitor; Furine Inhibitor III; PAEC4 Inhibitor, PC1/3 Inhibitor, PC4 Inhibitor, PC5/6 Inhibitor 参考 参考 Becker, G., et al. 2012. J Biol Chem 287, 21992. 产品信息 形式 White solid 配方 Supplied as a trifluoroacetate salt. Hill配方 C₃₅H₅₅N₁₅O₄ 化学配方 C₃₅H₅₅N₁₅O₄ Molar Mass 749.91 可逆 Y 结构配方图像 生物信息 主靶 Furin, PAEC4, PC1/3, PC4, and PC5/6 主靶Ki 16 pM 纯度 ≥98% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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