merck millipore,默克密理博,FCMAB405F,Milli-Mark™ Anti-PLK1-FITC Antibody, clone 35-206

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
M	FC	M	FITC	Monoclonal Antibody

描述
产品目录编号	FCMAB405F
商名	Milli-Mark
描述	Milli-Mark™ Anti-PLK1-FITC Antibody, clone 35-206
Alternate Names	polo like kinase Polo-like kinase 1 Serine/threonine-protein kinase 13 cell cycle regulated protein kinase polo (Drosophia)-like kinase
背景信息	Polo-like Kinase 1 (PLK-1) is a serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. Expressed PLK-1 protein accumulates to a maximum during the G2 and M phases, declines to a nearly undetectable level following mitosis and throughout G1 phase, and then begins to accumulate again during S phase.

产品信息
格式	FITC
控制	NIH-3T3 cells
演示	Purified mouse monoclonal IgG1κ conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.

应用
应用	Milli-Mark Anti-PLK1-FITC Antibody, clone 35-206 is an antibody against PLK1 for use in FC.
主要应用	Flow Cytometry

生物信息
免疫原品种	6 histidine-tagged full length fusion protein corresponding to human polo-like kinase 1 (PLK1).
克隆	35-206
宿主	Mouse
特异性	Antibody recognizes PLK1.
同种型	IgG2b
品种反应性	Mouse
Species Reactivity Note	Tested and passed on Mouse. Unconjugated version Cat. No. 05-844 is predicted to react with Human based on immunogen design (This target is a human immunogen).
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_005021
基因符号	STPK13 PLK1 PLK PLK-1
纯化方法	Protein A Purified
UniProt编号	P53350
UniProt汇总	FUNCTION: SwissProt: P53350 # May be required for cell division and may have a role during G1 or S phase. SIZE: 603 amino acids; 68255 Da SUBUNIT: Interacts with CEP170 and EVI5. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Placenta and colon. DEVELOPMENTAL STAGE: Accumulates to a maximum during the G2 and M phases, declines to a nearly undetectable level following mitosis and throughout G1 phase, and then begins to accumulate again during S phase. PTM: Catalytic activity is enhanced by phosphorylation of Thr-210 and/or Ser-137. & Autophosphorylation and phosphorylation of Ser-137 are not significant events during activation of PLK1 in M phase. SIMILARITY: SwissProt: P53350 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. & Contains 2 POLO box domains. & Contains 1 protein kinase domain.

产品使用声明
质量保证	Evaluated by flow cytometry using NIH-3T3 cells.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.

包装信息
数量	100 tests

merck millipore,默克密理博,FCMAB405F,Milli-Mark™ Anti-PLK1-FITC Antibody, clone 35-206

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