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品种反应性 主要应用 宿主 格式 抗体类型 M, H, R, B, Eq WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABT121 描述 Anti-T-cadherin (CDH13) Antibody Alternate Names - T-cadherin
- Cadherin-13
- Heart cadherin
- H-cadherin
- P105
- Truncated cadherin
- T-cad
背景信息 T-cadherin (CDH13), also known as Cadherin 13, is a member of the cadherin superfamily. This protein is unique from its other family members in that it lacks the cytoplasmic domains and is anchored to the cells membrane through the GPI anchor. T-cadherin is widely expressed in the cardiovascular system. Mutations in T-cadherin have been associated with many types of cancer. 产品信息 格式 Affinity Purified 控制 - Human heart tissue lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-T-cadherin (CDH13) Antibody detects level of T-cadherin (CDH13) & has been published & validated for use in WB, IH(P). 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected T-cadherin in human brain and human heart tissues. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human T-cadherin at the Cadherin 1 domain. 表位 Cadherin 1 domain 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes T-cadherin at the Cadherin 1 domain. This antibody detects the ~130 kDa pro-protein and the proteolytically cleaved ~105 kDa mature isoforms. (Denzel, M., et al. (2010). J Clin Invest.120(12):4342–4352.) 品种反应性 MouseHumanRatBovineHorse Species Reactivity Note Demonstrated to react with Human and Rat. Predicted to react with Bovine, Equine, and Mouse based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001248
Entrez基因汇总 This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]. 基因符号 - CDHH
- CDH13
纯化方法 Affinity purified UniProt编号 - P55290
UniProt汇总 FUNCTION: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor › GPI-anchor
TISSUE SPECIFICITY: Highly expressed in heart. In the CNS, expressed in cerebral cortex, medulla, hippocampus, amygdala, thalamus and substantia nigra. No expression detected in cerebellum or spinal cord.
DEVELOPMENTAL STAGE: Expressed at higher levels in adult brain than in developing brain.
SEQUENCE SIMILARITIES: Contains 5 cadherin domains.产品使用声明 质量保证 Evaluated by Western Blot in human heart tissue lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody detected T-cadherin on 10 µg of human heart tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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