merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB3866,Anti-Heterochromatin Antibody

  • merck millipore,默克密理博,MAB3866,Anti-Heterochromatin Antibody

    产品名称：Anti-Heterochromatin Antibody
    产品型号：MAB3866
    Detect Heterochromatin with Anti-Heterochromatin Antibody (Mouse Monoclonal Antibody), that has been shown to work in ELISA, FC, ICC & IHC.

    merck millipore,默克密理博,MAB3866,Anti-Heterochromatin Antibody

  • 产品介绍
  • merck millipore,默克密理博,MAB3866,Anti-Heterochromatin Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    AIHC, ELISA, FC, ICCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB3866
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Heterochromatin Antibody
    产品信息
    格式 Purified
    演示 Partially purified culture supernatant. Liquid in PBS.
    应用
    应用 Detect Heterochromatin with Anti-Heterochromatin Antibody (Mouse Monoclonal Antibody), that has been shown to work in ELISA, FC, ICC & IHC.
    主要应用
    • Immunohistochemistry
    • ELISA
    • Flow Cytometry
    • Immunocytochemistry
    应用说明 Immunocytochemistry: 5-10 μg/mL on 2% paraformaldehyde fixed cells (10 minutes at room temperature)

    Immunohistochemistry: 5-10 μg/mL on paraformaldehyde or B5 fixed tissue sections.

    Flow cytometry: 5-10 μg/mL using 2% paraformaldehyde fixed cells.

    ELISA, direct and indirect

    Optimal working dilutions must be determined by end user.

    STAINING PATTERN:

    Stains heterochromatic regions of cell nucleus.
    生物信息
    免疫原品种 Human Raji cell nuclei
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Reacts with heterochromatin. The antibody is useful for staining cell nuclei, especially those rich in heterochromatin or highly folded DNA.
    同种型 IgM
    品种反应性 All
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_012117.1
    Entrez基因汇总 Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing.[supplied by OMIM]
    基因符号
    • HP1Hs-alpha
    • CBX5
    • HP1-ALPHA
    • HP1A
    • HP1
    UniProt编号
    • P45973
    UniProt汇总 FUNCTION: SwissProt: P45973 # Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Can interact with lamin B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
    SIZE: 191 amino acids; 22225 Da
    SUBUNIT: Interacts with SUV420H1 and SUV420H2 (By similarity). Interacts directly with ATRX, CHAF1A, LBR, NIPBL, SP100, STAM2 and TRIM28 via the chromoshadow domain. Can interact directly with CBX3 via the chromoshadow domain. Interacts with histone H3 methylated at 'Lys-9'. Interacts with MIS12 and C20orf127.
    SUBCELLULAR LOCATION: Nucleus. Centromere. Note=Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase.
    PTM: Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle (By similarity). Phosphorylated during interphase and possibly hyper- phosphorylated during mitosis.
    SIMILARITY: SwissProt: P45973 ## Contains 2 chromo domains.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MAB3866,Anti-Heterochromatin Antibody

上一件merck millipore产品：merck millipore,默克密理博,14-1060,Human Recombinant Hp1β (CBX1)
下一件merck millipore产品：merck millipore,默克密理博,36-011,Anti-nitro-α/β-Synuclein Antibody, clone nSyn12


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